ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Searching for the mismatch negativity in primary auditory cortex of the awake monkey: deviance detection or stimulus specific adaptation?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 179 citations in OpenAlex.
- Distinct millisecond-scale click-train patterns evoke discriminable behavioral and neural responses in humans and rats.PLoS biology · 2026Article
- Critical Review on the Development and Evolution of Beat Perception.Annals of the New York Academy of Sciences · 2026Review
- Behavioral engagement and stimulus regularities coordinate auditory-prefrontal network activity.PLoS biology · 2026Article
- Computational Modelling of Novelty Detection in the Mismatch Negativity Protocols and Its Impairments in Schizophrenia.The European journal of neuroscience · 2026Article
- Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus.PLoS biology · 2026Article
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- Measuring the Genuine Mismatch Negativity in the Auditory Multi-Feature Paradigm.The European journal of neuroscience · 2026Article
- Neurophysiology of mismatch negativity generation: a biophysical modeling study.bioRxiv : the preprint server for biology · 2025Article
- Computational modelling of novelty detection in the mismatch negativity protocols and its impairments in schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Modulation of Auditory Novelty Processing by Dexmedetomidine and Natural Sleep: A Human Intracranial Electrophysiology Study.The European journal of neuroscience · 2025Article
- Complementary functional profiles of mismatch responses mediated by adaptation and deviance detection point to two distinct auditory short-term memory systems.Journal of neurophysiology · 2025Article
- Location-specific neural facilitation in marmoset auditory cortex.Nature communications · 2025Article
- Article
- Deviance detection and regularity sensitivity in dissociated neuronal cultures.Frontiers in neural circuits · 2025Article
- Hierarchical Temporal Processing in the Primate Thalamocortical System: Insights from Nonlinguistic Structured Stimuli.Research (Washington, D.C.) · 2025Article
- Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Laminar pattern of sensory-evoked dynamic high-frequency oscillatory activity in the macaque auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Is source-resolved magnetoencephalographic mismatch negativity a viable biomarker for early psychosis?The European journal of neuroscience · 2024Article
- Probing Beat Perception with Event-Related Potentials (ERPs) in Human Adults, Newborns, and Nonhuman Primates.Advances in experimental medicine and biology · 2024Review
- Decoding effects of psychoactive drugs in a high-dimensional space of eye movements in monkeys.National science review · 2023Article
43 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
The mismatch negativity (MMN) is a preattentive component of the auditory event-related potential that is elicited by a change in a repetitive acoustic pattern. While MMN has been extensively used in human electrophysiological studies of auditory processing, the neural mechanisms and brain regions underlying its generation remain unclear. We investigate possible homologs of the MMN in macaque primary auditory cortex (A1) using a frequency oddball paradigm in which rare "deviant" tones are randomly interspersed among frequent "standard" tones. Standards and deviants had frequencies equal to the best frequency (BF) of the recorded neural population or to a frequency that evoked a response half the amplitude of the BF response. Early and later field potentials, current source density components, multiunit activity, and induced high-gamma band responses were larger when elicited by deviants than by standards of the same frequency. Laminar analysis indicated that differences between deviant and standard responses were more prominent in later activity, thus suggesting cortical amplification of initial responses driven by thalamocortical inputs. However, unlike the human MMN, larger deviant responses were characterized by the enhancement of "obligatory" responses rather than the introduction of new components. Furthermore, a control condition wherein deviants were interspersed among many tones of variable frequency replicated the larger responses to deviants under the oddball condition. Results suggest that differential responses under the oddball condition in macaque A1 reflect stimulus-specific adaptation rather than deviance detection per se. We conclude that neural mechanisms of deviance detection likely reside in cortical areas outside of A1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.