ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Differential Autoregulation of Serotonin Secretion at Different Structures of Serotonergic Neurons.International journal of molecular sciences · 2026Review
- Nonlinear recurrent inhibition through facilitating serotonin release in the raphe.Nature neuroscience · 2025Article
- Wiring and Volume Transmission: An Overview of the Dual Modality for Serotonin Neurotransmission.ACS chemical neuroscience · 2023Review
- Neuronal Redevelopment and the Regeneration of Neuromodulatory Axons in the Adult Mammalian Central Nervous System.Frontiers in cellular neuroscience · 2022Review
- Activation of the glucocorticoid receptor rapidly triggers calcium-dependent serotonin release in vitro.CNS neuroscience & therapeutics · 2021Article
- Rewiring of the Serotonin System in Major Depression.Frontiers in psychiatry · 2021Review
- Extrasynaptic Communication.Frontiers in molecular neuroscience · 2021Article
- Serotonergic Modulation of Persistent Inward Currents in Serotonergic Neurons of Medulla in ePet-EYFP Mice.Frontiers in neural circuits · 2021Article
- GPCR-Based Dopamine Sensors-A Detailed Guide to Inform Sensor Choice for In vivo Imaging.International journal of molecular sciences · 2020Review
- Article
- Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.Current biology : CB · 2019Article
- Embracing diversity in the 5-HT neuronal system.Nature reviews. Neuroscience · 2019Review
- Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels.General psychiatry · 2019Article
- Label-free imaging of neurotransmitters in live brain tissue by multi-photon ultraviolet microscopy.Neuronal signaling · 2018Review
- Positive regulation of raphe serotonin neurons by serotonin 2B receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA.Cell discovery · 2018Article
- Somato-Dendritic Regulation of Raphe Serotonin Neurons; A Key to Antidepressant Action.Frontiers in neuroscience · 2018Review
- Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABAScientific reports · 2017Article
- Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities.The European journal of neuroscience · 2017Article
- Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons.The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Serotonin released within the dorsal raphe nucleus (DR) induces feedback inhibition of serotonin neuron activity and consequently regulates mood-controlling serotonin release throughout the forebrain. Serotonin packaged in vesicles is released in response to action potentials by the serotonin neuron soma and terminals, but the potential for release by dendrites is unknown. Here, three-photon microscopy imaging of endogenous serotonin in living rat brain slice, immunofluorescence, and immunogold electron microscopy detection of VMAT2 (vesicular monoamine transporter 2) establish the presence of vesicular serotonin within DR dendrites. Furthermore, activation of glutamate receptors is shown to induce vesicular serotonin release from dendrites. However, unlike release from the soma and terminals, dendritic serotonin release is independent of action potentials, relies on L-type Ca(2+) channels, is induced preferentially by NMDA, and displays distinct sensitivity to the selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine. The unique control of dendritic serotonin release has important implications for DR physiology and the antidepressant action of SSRIs, dihydropyridines, and NMDA receptor antagonists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.