Trial reportThe American journal of tropical medicine and hygiene2012
Integrated community case management of fever in children under five using rapid diagnostic tests and respiratory rate counting: a multi-country cluster randomized trial.
Trial report in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 9 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Adding rapid diagnostic tests to community-based programmes for treating malaria.The Cochrane database of systematic reviews · 2022Pooled it
- Integrated community case management of childhood illness in low- and middle-income countries.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Use of malaria RDTs in various health contexts across sub-Saharan Africa: a systematic review.BMC public health · 2017Pooled it
- Health workers' compliance to rapid diagnostic tests (RDTs) to guide malaria treatment: a systematic review and meta-analysis.Malaria journal · 2016Pooled it
- Community health workers and stand-alone or integrated case management of malaria: a systematic literature review.The American journal of tropical medicine and hygiene · 2014Pooled it
- Success or failure of critical steps in community case management of malaria with rapid diagnostic tests: a systematic review.Malaria journal · 2014Pooled it
- Pooled it
- Trial
- Improving rational use of ACTs through diagnosis-dependent subsidies: Evidence from a cluster-randomized controlled trial in western Kenya.PLoS medicine · 2018Trial
- Trial
- Appropriate targeting of artemisinin-based combination therapy by community health workers using malaria rapid diagnostic tests: findings from randomized trials in two contrasting areas of high and low malaria transmission in south-western Uganda.Tropical medicine & international health : TM & IH · 2016Trial
- Trial
- Healthcare providers' knowledge, perceptions and practices of malaria control strategies in the Republic of Guinea: insights from a qualitative study.BMJ global health · 2026Article
- Antibiotic stewardship and point-of-care testing for children in 25 low-income and lower-middle-income countries: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Observational
- Antibiotic Stewardship in Retail Pharmacies and the Access-Excess Challenge in China: A Policy Review.Antibiotics (Basel, Switzerland) · 2022Review
- Rapid Diagnostic Tests to Guide Case Management of and Improve Antibiotic Stewardship for Pediatric Acute Respiratory Illnesses in Resource-Constrained Settings: a Prospective Cohort Study in Southwestern Uganda.Microbiology spectrum · 2021Observational
- Community acceptance, satisfaction, and support for case management of malaria of various degrees in selected rural communities in Ibadan, Oyo-State.Ghana medical journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence on the impact of using diagnostic tests in community case management of febrile children is limited. This effectiveness trial conducted in Burkina Faso, Ghana, and Uganda, compared a diagnostic and treatment package for malaria and pneumonia with presumptive treatment with anti-malarial drugs; artemisinin combination therapy (ACT). We enrolled 4,216 febrile children between 4 and 59 months of age in 2009-2010. Compliance with the malaria rapid diagnostic test (RDT) results was high in the intervention arm across the three countries, with only 4.9% (17 of 344) of RDT-negative children prescribed an ACT. Antibiotic overuse was more common: 0.9% (4 of 446) in Uganda, 38.5% (114 of 296) in Burkina Faso, and 44.6% (197 of 442) in Ghana. Fever clearance was high in both intervention and control arms at both Day 3 (97.8% versus 96.9%, P = 0.17) and Day 7 (99.2% versus 98.8%, P = 0.17). The use of diagnostic tests limits overuse of ACTs. Its impact on antibiotic overuse and on fever clearance is uncertain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.