ArticleNeurology2012
Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study.
Article in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 89 citations in OpenAlex.
- The established status epilepticus trial 2013.Epilepsia · 2013Trial
- Febrile Seizures: Clinical Insights From Decades of the National Institutes of Neurological Diseases and Stroke (NINDS) Support.Epilepsy currents · 2026Review
- Febrile status epilepticus and epileptogenesis: The FEBSTAT study.Epilepsia open · 2025Article
- Frontiers in EEG as a tool for the management of pediatric epilepsy: Past, present, and future.Epilepsia open · 2025Article
- Strategies to innovate emergency care of status epilepticus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Complex Febrile Seizures: Usual and the Unusual.Indian journal of pediatrics · 2025Review
- Predicting seizure recurrence after an initial seizure-like episode from routine clinical notes using large language models: a retrospective cohort study.The Lancet. Digital health · 2023Article
- Exploring the Age-Old Question: What Is the Predictive Value of EEG for Future Epilepsy in Children With Complex Febrile Seizures?Journal of child neurology · 2023Article
- Why ketamine.Epilepsy & behavior : E&B · 2023Review
- Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort).Epilepsia · 2021Article
- Children's Neurological Status Epilepticus and Poor Prognostic Factors through Electroencephalogram Image under Composite Domain Analysis Algorithm.Journal of healthcare engineering · 2021Article
- α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus.Annals of neurology · 2020Article
- Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models.Annals of clinical and translational neurology · 2017Article
- Early-life febrile seizures worsen adult phenotypes in Scn1a mutants.Experimental neurology · 2017Article
- Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study.AJNR. American journal of neuroradiology · 2016Article
- Seizures and Epilepsies due to Channelopathies and Neurotransmitter Receptor Dysfunction: A Parallel between Genetic and Immune Aspects.Molecular syndromology · 2016Review
- Article
- Status Epilepticus.Cold Spring Harbor perspectives in medicine · 2016Review
- Epilepsy in children with a history of febrile seizures.Korean journal of pediatrics · 2016Article
- Convulsion and cerebellar ataxia associated with maternally inherited diabetes and deafness: a case report.Clinical case reports · 2015Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe FEBSTAT (Consequences of Prolonged Febrile Seizures) study is prospectively addressing the relationships among serial EEG, MRI, and clinical follow-up in a cohort of children followed from the time of presentation with febrile status epilepticus (FSE).
methodsWe recruited 199 children with FSE within 72 hours of presentation. Children underwent a detailed history, physical examination, MRI, and EEG within 72 hours. All EEGs were read by 2 teams and then conferenced. Associations with abnormal EEG were determined using logistic regression. Interrater reliability was assessed using the κ statistic.
resultsOf the 199 EEGs, 90 (45.2%) were abnormal with the most common abnormality being focal slowing (n = 47) or attenuation (n = 25); these were maximal over the temporal areas in almost all cases. Epileptiform abnormalities were present in 13 EEGs (6.5%). In adjusted analysis, the odds of focal slowing were significantly increased by focal FSE (odds ratio [OR] = 5.08) and hippocampal T2 signal abnormality (OR = 3.50) and significantly decreased with high peak temperature (OR = 0.18). Focal EEG attenuation was also associated with hippocampal T2 signal abnormality (OR = 3.3).
conclusionsFocal EEG slowing or attenuation are present in EEGs obtained within 72 hours of FSE in a substantial proportion of children and are highly associated with MRI evidence of acute hippocampal injury. These findings may be a sensitive and readily obtainable marker of acute injury associated with FSE.
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