ArticleInternational journal of cancer2013
Altered local and systemic immune profiles underlie lymph node metastasis in breast cancer patients.
Article in International journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Large-scale analysis of temporal gene expression variation in peripheral blood.Nature communications · 2026Article
- Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An immune-related seven-gene signature for predicting lymph node metastasis in breast cancer.Frontiers in molecular biosciences · 2025Article
- Two Different Immune Profiles Are Identified in Sentinel Lymph Nodes of Early-Stage Breast Cancer.Cancers · 2024Article
- Alteration of the immune microenvironment in the axillary metastatic lymph nodes of luminal A breast cancer patients.World journal of surgical oncology · 2024Article
- Prognostic and predictive impact of gene expression in node-positive early breast cancer patients receiving dose-dense versus standard-dose adjuvant chemotherapy.Molecular oncology · 2023Article
- Blood-Based mRNA Tests as Emerging Diagnostic Tools for Personalised Medicine in Breast Cancer.Cancers · 2023Review
- A nomogram based on genotypic and clinicopathologic factors to predict the non-sentinel lymph node metastasis in Chinese women breast cancer patients.Frontiers in oncology · 2023Article
- The Multifaceted Effects of Breast Cancer on Tumor-Draining Lymph Nodes.The American journal of pathology · 2021Review
- A six-gene signature related with tumor mutation burden for predicting lymph node metastasis in breast cancer.Translational cancer research · 2021Article
- Expression pattern, regulation, and clinical significance of TOX in breast cancer.Cancer immunology, immunotherapy : CII · 2021Article
- Article
- Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives.Journal of mammary gland biology and neoplasia · 2020Review
- Primary and metastatic breast tumors cross-talk to influence immunotherapy responses.Oncoimmunology · 2020Article
- Systemic dysfunction and plasticity of the immune macroenvironment in cancer models.Nature medicine · 2020Article
- Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients.Nature communications · 2020Article
- Metastatic Breast Cancer and Pre-Diagnostic Blood Gene Expression Profiles-The Norwegian Women and Cancer (NOWAC) Post-Genome Cohort.Frontiers in oncology · 2020Article
- The significance of cytokine-producing B cells in breast tumor-draining lymph nodes.Cellular oncology (Dordrecht, Netherlands) · 2019Article
- Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients.Breast cancer research : BCR · 2018Review
- Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Cancer-mediated immune dysfunction contributes to tumor progression and correlates with patient outcome. Metastasis to tumor draining lymph nodes (TDLNs) is an important step in breast cancer progression and is used to predict patient outcome and survival. Although lymph nodes are important immune organs, the role of immune cells in TDLNs has not been thoroughly investigated. We hypothesized that the host immune response in node negative (NN) patients is more intact and thereby can resist tumor invasion compared to node positive (NP) patients. As such, lymph node metastasis requires breakdown of the host immune response in addition to escape of cancer cells from the tumor. To investigate the immunological differences between NN and NP breast cancer patients, we purified and profiled immune cells from the three major compartments where cancer and immune cells interact: tumor, TDLNs and peripheral blood. Significant down-regulation of genes associated with immune-related pathways and up-regulation of genes associated with tumor-promoting pathways was consistently observed in NP patients' TDLNs compared to NN patients. Importantly, these signatures were seen even in NP patients' tumor-free TDLNs, suggesting that such immune changes are not driven solely by local tumor invasion. Furthermore, similar patterns were also observed in NP patients' tumor and blood immune cells, suggesting that immunological differences between NN and NP patients are systemic. Together, these findings suggest that alterations in overall immune function may underlie risk for LN metastasis in breast cancer patients.
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