ArticleInternational journal of cancer2013
Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
Article in International journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis on prevalence and attribution of human papillomavirus types 52 and 58 in cervical neoplasia worldwide.PloS one · 2014Pooled it
- Genetic variation of human papillomavirus type 39 E6 and E7 genes in central China.Virology journal · 2026Article
- Prevalence of human papillomavirus genotypes in women of different ethnicity from rural northwestern Ecuador.BMC global and public health · 2024Article
- Changes in the Incidence and Human Papillomavirus-Positive Portion of Oropharyngeal Squamous Cell Carcinoma in Hong Kong.Cancers · 2024Article
- E7 Oncogene HPV58 Variants Detected in Northeast Brazil: Genetic and Functional Analysis.Microorganisms · 2023Article
- Characteristics of human papillomavirus infection among females and the genetic variations of HPV18 and HPV58 in Henan province, China.Scientific reports · 2023Article
- Characterization of the Human Papillomavirus 16 Oncogenes in K14HPV16 Mice: Sublineage A1 Drives Multi-Organ Carcinogenesis.International journal of molecular sciences · 2022Article
- Human Papillomavirus (HPV) Prevalence and Type Distribution in Urban Areas of Malaysia.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia.Cancers · 2021Review
- High-risk HPV genotypes in Zimbabwean women with cervical cancer: Comparative analyses between HIV-negative and HIV-positive women.PloS one · 2021Article
- HPV58 E7 Protein Expression Profile in Cervical Cancer and CIN with Immunohistochemistry.Journal of Cancer · 2021Article
- UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.Biomolecules · 2020Article
- Article
- Whole-Genome Analysis of Cervical Human Papillomavirus Type 35 from rural Zimbabwean Women.Scientific reports · 2020Article
- Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.Journal of virology · 2020Article
- The contribution of Latin American research to HPV epidemiology and natural history knowledge.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Review
- Machine Learning Interpretation of Extended Human Papillomavirus Genotyping by Onclarity in an Asian Cervical Cancer Screening Population.Journal of clinical microbiology · 2019Article
- Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China.Virology journal · 2019Article
- Oncogenic comparison of human papillomavirus type 58 E7 variants.Journal of cellular and molecular medicine · 2019Article
- TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration.Scientific reports · 2019Article
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32 authors.
Funding
Abstract
Human papillomavirus (HPV) 58 accounts for a notable proportion of cervical cancers in East Asia and parts of Latin America, but it is uncommon elsewhere. The reason for such ethnogeographical predilection is unknown. In our study, nucleotide sequences of E6 and E7 genes of 401 HPV58 isolates collected from 15 countries/cities across four continents were examined. Phylogenetic relationship, geographical distribution and risk association of nucleotide sequence variations were analyzed. We found that the E6 genes of HPV58 variants were more conserved than E7. Thus, E6 is a more appropriate target for type-specific detection, whereas E7 is more appropriate for strain differentiation. The frequency of sequence variation varied geographically. Africa had significantly more isolates with E6-367A (D86E) but significantly less isolates with E6-203G, -245G, -367C (prototype-like) than other regions (p ≤ 0.003). E7-632T, -760A (T20I, G63S) was more frequently found in Asia, and E7-793G (T74A) was more frequent in Africa (p < 0.001). Variants with T20I and G63S substitutions at E7 conferred a significantly higher risk for cervical intraepithelial neoplasia grade III and invasive cervical cancer compared to other HPV58 variants (odds ratio = 4.44, p = 0.007). In conclusion, T20I and/or G63S substitution(s) at E7 of HPV58 is/are associated with a higher risk for cervical neoplasia. These substitutions are more commonly found in Asia and the Americas, which may account for the higher disease attribution of HPV58 in these areas.
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