ArticleEnvironmental toxicology and chemistry2013
Interactions between chemical and climate stressors: a role for mechanistic toxicology in assessing climate change risks.
Article in Environmental toxicology and chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 368 citations in OpenAlex.
- Emerging Environmental Toxicants Undermine Reproductive Success in Aquatic Animals: A Narrative Review.Journal of xenobiotics · 2026Review
- Time- and Temperature-Dependent Effects of PHBV on Physiological Responses in Brine Shrimp.Toxics · 2026Article
- Crawling towards complex interactions: the impact of 6PPD-quinone and increased temperatures on the freshwater snail Ampullaceana balthica.Ecotoxicology (London, England) · 2026Article
- Article
- The Individual and Combined Effects of Warming and Atrazine on Lithobates pipiens Phenotypes: Implications for Frog Declines.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Stressor interactions affect myxozoan abundance in a 42-year dataset from the Pearl River, Louisiana, USA.Parasitology · 2026Article
- When Heat Meets Pollutants: Integrating Degree-Days and Chemical Activity Concepts for the Assessment of Temperature-Driven Toxicity.Environmental science & technology · 2026Article
- Acidification, warming and cadmium exposure disrupt zebrafish calcium metabolism, bone formation and swimming activity.The Journal of experimental biology · 2026Article
- Reproductive Impact of Natural, Synthetic and Emerging Chemicals on Wildlife and Domestic Animals.Advances in experimental medicine and biology · 2026Review
- Scientific and Regulatory Perspectives on Chemical Risk Assessment of Pesticides in the European Union.Journal of xenobiotics · 2025Review
- Pre-Exposure to Chemicals Increases Springtail Vulnerability to High Temperatures.Global change biology · 2025Article
- Asymmetric Micro-Evolutionary Responses in a Warming World: Heat-Driven Adaptation Enhances Metal Tolerance in a Planktonic Rotifer, but Not Vice Versa.Global change biology · 2025Article
- Mental health impacts of particulate matter exposure and non-optimal temperature among rural and urban children in eastern China.Npj mental health research · 2025Article
- Sea temperature and pollution are associated with infectious disease mortality in short-beaked common dolphins.Communications biology · 2025Article
- Article
- Climate change drives persistent organic pollutant dynamics in marine environments.Communications earth & environment · 2025Article
- Animal personality in multiple stressor environments: the evolutionary ecology of among-individual differences in responses to stressor suites.Proceedings. Biological sciences · 2024Review
- Life Table Study ofInsects · 2024Article
- Pathogenesis of PMEpigenomes · 2024Review
- Endocrine responses to environmental variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Incorporation of global climate change (GCC) effects into assessments of chemical risk and injury requires integrated examinations of chemical and nonchemical stressors. Environmental variables altered by GCC (temperature, precipitation, salinity, pH) can influence the toxicokinetics of chemical absorption, distribution, metabolism, and excretion as well as toxicodynamic interactions between chemicals and target molecules. In addition, GCC challenges processes critical for coping with the external environment (water balance, thermoregulation, nutrition, and the immune, endocrine, and neurological systems), leaving organisms sensitive to even slight perturbations by chemicals when pushed to the limits of their physiological tolerance range. In simplest terms, GCC can make organisms more sensitive to chemical stressors, while alternatively, exposure to chemicals can make organisms more sensitive to GCC stressors. One challenge is to identify potential interactions between nonchemical and chemical stressors affecting key physiological processes in an organism. We employed adverse outcome pathways, constructs depicting linkages between mechanism-based molecular initiating events and impacts on individuals or populations, to assess how chemical- and climate-specific variables interact to lead to adverse outcomes. Case examples are presented for prospective scenarios, hypothesizing potential chemical-GCC interactions, and retrospective scenarios, proposing mechanisms for demonstrated chemical-climate interactions in natural populations. Understanding GCC interactions along adverse outcome pathways facilitates extrapolation between species or other levels of organization, development of hypotheses and focal areas for further research, and improved inputs for risk and resource injury assessments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.