Evidence map›Paper›PMID 23135760›Full record

ArticleGut2013

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women.

Evelyne M Dewulf, Patrice D Cani, Sandrine P Claus, Susana Fuentes, Philippe G B Puylaert, Audrey M Neyrinck, Laure B Bindels, Willem M de Vos, Glenn R Gibson, Jean-Paul Thissen and 1 more

2 registry-linked trialsOpen access · hybridAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 358 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
358citing papers in PubMed, 9 pooled it
30.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02642172 nacompletednot on this mapstarted 2016, after this paper: background citation

A Randomized, Double - Blind Study With Two Parallel Arms for 4 Months (20 Weeks), Evaluating the Effectiveness of the Prebiotics in Patients With Non-alcoholic Liver Disease.

TypeinterventionalSponsorKaplan Medical CenterRan2016 to 2023Enrolled24ConditionsNon-alcoholic Fatty Liver Disease, Metabolic SyndromeArmsITF (Inulin/OFS 75/25), Placebo
NCT04543877 early_phase1completednot on this mapstarted 2022, after this paper: background citation

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2022 to 2025Enrolled60ConditionsInflammation, Vaccine, Intestinal Permeability, Typhoid FeverArmsInulin, Maltodextrin, Ty21a Typhoid Fever Vaccine
3 · Its place in the literature

Who cites it

358 citing papers in PubMed, 9 syntheses or guidelines pooled it, 810 citations in OpenAlex.

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  8. The effects of inulin on gut microbial composition: a systematic review of evidence from human studies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
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298 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Evelyne M DewulfMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Avenue E. Mounier 73, PO Box B1.73.11, 1200 Brussels, Belgium.
Patrice D Cani
Sandrine P Claus
Susana Fuentes
Philippe G B Puylaert
Audrey M Neyrinck
Laure B Bindels
Willem M de Vos
Glenn R Gibson
Jean-Paul Thissen
Nathalie M Delzenne
UCLouvain · BEWageningen University & Research · NLUniversity of Reading · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women.

methodsA double blind, placebo controlled, intervention study was performed with 30 obese women treated with ITF prebiotics (inulin/oligofructose 50/50 mix; n=15) or placebo (maltodextrin; n=15) for 3 months (16 g/day). Blood, faeces and urine sampling, oral glucose tolerance test, homeostasis model assessment and impedancemetry were performed before and after treatment. The gut microbial composition in faeces was analysed by phylogenetic microarray and qPCR analysis of 16S rDNA. Plasma and urine metabolic profiles were analysed by 1H-NMR spectroscopy.

resultsTreatment with ITF prebiotics, but not the placebo, led to an increase in Bifidobacterium and Faecalibacterium prausnitzii; both bacteria negatively correlated with serum lipopolysaccharide levels. ITF prebiotics also decreased Bacteroides intestinalis, Bacteroides vulgatus and Propionibacterium, an effect associated with a slight decrease in fat mass and with plasma lactate and phosphatidylcholine levels. No clear treatment clustering could be detected for gut microbial analysis or plasma and urine metabolomic profile analyses. However, ITF prebiotics led to subtle changes in the gut microbiota that may importantly impact on several key metabolites implicated in obesity and/or diabetes.

conclusionsITF prebiotics selectively changed the gut microbiota composition in obese women, leading to modest changes in host metabolism, as suggested by the correlation between some bacterial species and metabolic endotoxaemia or metabolomic signatures.

Indexed as

PrebioticsAdolescentAdultAnthropometryBacteriaBacterial Typing TechniquesBody Mass IndexDouble-Blind MethodFecesFemaleHumansInulinMetabolomeMetagenomeMiddle AgedObesityInulinPrebioticsIntestinal BacteriaNutritionObesityPrebiotic

Identifiers

PMID23135760
PMCPMC3711491
OpenAlexW2170274997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.