Evidence map›Paper›PMID 23135709›Full record

ArticleJournal of virology2013

Expression of prototype foamy virus pol as a Gag-Pol fusion protein does not change the timing of reverse transcription.

Dana L Jackson, Eun-Gyung Lee, Maxine L Linial

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dana L JacksonDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Eun-Gyung Lee
Maxine L Linial
Fred Hutch Cancer Center · US

Funding

VIRAL CODED FUNCTIONS IN ROUS SARCOMA VIRUSR01CA018282 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LINIAL, MAXINE L · 1985 to 2011
$5.0M
NCI NIH HHS R01 CA018282NCI NIH HHS R01 CA 18282
6 · The paper itself

Abstract

Foamy viruses are retroviruses whose Pol protein is synthesized without Gag from a spliced mRNA. Unlike orthoretroviruses, reverse transcription occurs during viral assembly, leading to DNA-containing virions. When prototype foamy virus Pol is expressed as an orthoretroviral-like Gag-Pol fusion protein, reverse transcription also occurs late in viral replication, as measured by the timing of reverse transcriptase sensitivity to the inhibitor 3'-azido-3'deoxythymidine (AZT). Thus, timing of reverse transcription is intrinsic to Pol itself.

Indexed as

Gene Expression Regulation, ViralReverse TranscriptionCell LineFusion Proteins, gag-polHumansReverse Transcriptase InhibitorsRNA-Directed DNA PolymeraseSpumavirusVirus AssemblyZidovudineFusion Proteins, gag-polReverse Transcriptase InhibitorsRNA-Directed DNA PolymeraseZidovudine

Identifiers

PMID23135709
PMCPMC3554092
OpenAlexW2095861739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.