ArticleLab on a chip2013
Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
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- Alpha Particle-Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery.Molecular imaging and biology · 2023Review
- State of the art procedures towards reactive [EJNMMI radiopharmacy and chemistry · 2023Review
- Production of [Molecules (Basel, Switzerland) · 2022Article
- Economical droplet-based microfluidic production of [Scientific reports · 2021Article
- A simple and efficient automated microvolume radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2020Article
- The Current Role of Microfluidics in Radiofluorination Chemistry.Molecular imaging and biology · 2020Review
- Multi-GBq production of the radiotracer [RSC advances · 2020Article
- Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[EJNMMI radiopharmacy and chemistry · 2019Article
- Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production.EJNMMI radiopharmacy and chemistry · 2019Article
- Ultra-compact, automated microdroplet radiosynthesizer.Lab on a chip · 2019Article
- A novel multi-reaction microdroplet platform for rapid radiochemistry optimization.RSC advances · 2019Article
- Automated concentration of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2018Article
- An automated synthesizer for electrochemicalApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2017Article
- Digital Microfluidics: A New Paradigm for Radiochemistry.Molecular imaging · 2015Article
- Synthesis ofJournal of fluorine chemistry · 2015Article
- Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium.Journal of the American Chemical Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The very first microfluidic device used for the production of (18)F-labeled tracers for clinical research is reported along with the first human Positron Emission Tomography scan obtained with a microfluidically produced radiotracer. The system integrates all operations necessary for the transformation of [(18)F]fluoride in irradiated cyclotron target water to a dose of radiopharmaceutical suitable for use in clinical research. The key microfluidic technologies developed for the device are a fluoride concentration system and a microfluidic batch reactor assembly. Concentration of fluoride was achieved by means of absorption of the fluoride anion on a micro ion-exchange column (5 μL of resin) followed by release of the radioactivity with 45 μL of the release solution (95 ± 3% overall efficiency). The reactor assembly includes an injection-molded reactor chip and a transparent machined lid press-fitted together. The resulting 50 μL cavity has a unique shape designed to minimize losses of liquid during reactor filling and liquid evaporation. The cavity has 8 ports for gases and liquids, each equipped with a 2-way on-chip mechanical valve rated for pressure up to 20.68 bar (300 psi). The temperature is controlled by a thermoelectric heater capable of heating the reactor up to 180 °C from RT in 150 s. A camera captures live video of the processes in the reactor. HPLC-based purification and reformulation units are also integrated in the device. The system is based on "split-box architecture", with reagents loaded from outside of the radiation shielding. It can be installed either in a standard hot cell, or as a self-shielded unit. Along with a high level of integration and automation, split-box architecture allowed for multiple production runs without the user being exposed to radiation fields. The system was used to support clinical trials of [(18)F]fallypride, a neuroimaging radiopharmaceutical under IND Application #109,880.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.