ArticleMedicine and science in sports and exercise2013
Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress.
Article in Medicine and science in sports and exercise, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Low-dose ASA therapy does not alter core or skin temperature during hot-dry or warm-humid heat stress (PSU HEAT project).Physiological reports · 2025Trial
- Effects of pre-exercise glycerol supplementation on dehydration, metabolic, kinematic, and thermographic variables in international race walkers.Journal of the International Society of Sports Nutrition · 2024Trial
- Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms.Clinical science (London, England : 1979) · 2015Trial
- Oral clopidogrel improves cutaneous microvascular function through EDHF-dependent mechanisms in middle-aged humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Trial
- Identification of potentially heat-vulnerability increasing drugs - a narrative review.European journal of clinical pharmacology · 2026Review
- Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence.Temperature (Austin, Tex.) · 2024Article
- Climate change and the prevention of cardiovascular disease.American journal of preventive cardiology · 2022Review
- An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment.Sports medicine and health science · 2021Article
- Non-steroidal anti-inflammatory drugs on core body temperature during exercise: A systematic review.Journal of exercise science and fitness · 2021Review
- A 24 hour naproxen dose on gastrointestinal distress and performance during cycling in the heat.Sports medicine and health science · 2020Article
- Cyclooxygenase-1 and -2 modulate sweating but not cutaneous vasodilation during exercise in the heat in young men.Physiological reports · 2018Article
- Skin Temperature Measurement Using Contact Thermometry: A Systematic Review of Setup Variables and Their Effects on Measured Values.Frontiers in physiology · 2018Review
- Current concepts of active vasodilation in human skin.Temperature (Austin, Tex.) · 2017Review
- Deciphering glycomics and neuroproteomic alterations in experimental traumatic brain injury: Comparative analysis of aspirin and clopidogrel treatment.Electrophoresis · 2016Article
- Effect of Acetaminophen Ingestion on Thermoregulation of Normothermic, Non-febrile Humans.Frontiers in pharmacology · 2016Article
- Effects of Low-Dose Aspirin Therapy on Thermoregulation in Firefighters.Safety and health at work · 2015Article
- Do nitric oxide synthase and cyclooxygenase contribute to the heat loss responses in older males exercising in the heat?The Journal of physiology · 2015Article
- Evidence for cyclooxygenase-dependent sweating in young males during intermittent exercise in the heat.The Journal of physiology · 2014Article
- Heat-related illness in sports and exercise.Current reviews in musculoskeletal medicine · 2014Article
- Cyclooxygenase inhibition does not alter methacholine-induced sweating.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledAntithrombotic therapy with oral aspirin (ASA) or clopidogrel (CLO) (Plavix; Bristol-Myers Squibb, Bridgewater, NJ) is associated with an attenuated skin vasodilator response and a greater rate of rise in core temperature in healthy, middle-age individuals during passive heating in a water perfused suit. PURPOSE: The present double-blind, crossover study examined the functional consequences of 7 d of low-dose ASA (81 mg·d) versus CLO (75 mg·d) treatment in 14 healthy, middle-age (50-65 yr) men and women during passive heating in air (40 min at 30°C, 40% relative humidity) followed by exercise (60% V˙O2peak).
methodsOral temperature (Tor) was measured in the antechamber (23.0°C ± 0.1°C) before entering a warm environmental chamber. After 40 min of rest, subjects cycled on a recumbent cycle ergometer for up to 120 min. Esophageal temperature (Tes) and laser Doppler flux were measured continuously, and the latter was normalized to maximal cutaneous vascular conductance (%CVCmax).
resultsBefore entry into the environmental chamber there were no differences in Tor among treatments; however, after 40 min of rest in the heat, Tes was significantly higher for ASA and CLO versus placebo (37.2°C ± 0.1°C, 37.3°C ± 0.1°C, vs 37.0°C ± 0.1°C, both P < 0.001), a difference that persisted throughout exercise (P < 0.001 vs placebo). The mean body temperature thresholds for the onset of cutaneous vasodilation were shifted to the right for both ASA and CLO during exercise (P < 0.05).
conclusionASA and CLO resulted in elevated core temperatures during passive heat stress and shifted the onset of peripheral thermoeffector mechanisms toward higher body temperatures during exercise heat stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.