ArticleJournal of neurology2013
Olfactory bulb volume in patients with temporal lobe epilepsy.
Article in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Olfactory Testing in Temporal Lobe Epilepsy: a Systematic Review.Current neurology and neuroscience reports · 2020Pooled it
- A Quantitative Meta-analysis of Olfactory Dysfunction in Epilepsy.Neuropsychology review · 2019Pooled it
- Seizure treatment with olfactory training: a preliminary trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Trial
- Effect of low frequency stimulation of olfactory bulb and olfactory epithelium on epileptiform activity and synaptic plasticity following pentylenetetrazol administration in rats.Behavioral and brain functions : BBF · 2026Article
- Article
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- Quantitative analysis of the olfactory system in pediatric epilepsy: a magnetic resonance imaging studyDiagnostic and interventional radiology (Ankara, Turkey) · 2023Article
- Translational Considerations in the Development of Intranasal Treatments for Epilepsy.Pharmaceutics · 2023Review
- Patterns of Gray and White Matter Volume Alterations in Patients With Post-Traumatic Anosmia: A Voxel-Based Morphometry Study.Frontiers in neurology · 2022Article
- Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson's Disease.International journal of molecular sciences · 2021Review
- Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus.BMB reports · 2020Article
- Behavioral and EEGraphic Characterization of the Anticonvulsant Effects of the Predator Odor (TMT) in the Amygdala Rapid Kindling, a Model of Temporal Lobe Epilepsy.Frontiers in neurology · 2020Article
- Mechanisms Linking Olfactory Impairment and Risk of Mortality.Frontiers in neuroscience · 2020Review
- Neural plasticity in developing and adult olfactory pathways - focus on the human olfactory bulb.Journal of bioenergetics and biomembranes · 2019Review
- Influences of temporal lobe epilepsy and temporal lobe resection on olfaction.Journal of neurology · 2018Article
- Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer's Disease-Like Pattern.The international journal of neuropsychopharmacology · 2018Article
- Relation of the volume of the olfactory bulb to psychophysical measures of olfactory function.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Review
- The piriform cortex and human focal epilepsy.Frontiers in neurology · 2014Review
- The influences of age on olfaction: a review.Frontiers in psychology · 2014Review
- Plasticity of the human olfactory system: the olfactory bulb.Molecules (Basel, Switzerland) · 2013Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched healthy controls underwent olfactory testing by means of the Sniffin' Sticks testing device (measurement of odor threshold, and identification abilities). In addition, they underwent an MR scan with 2-mm-thick T2-weighted fast spin-echo images without interslice gap in the coronal plane covering the anterior and middle segments of the base of the skull. Olfactory function was significantly impaired in TLE patients compared to healthy controls both at threshold level and for odor identification (p < 0.001); in addition, OB volumes were smaller than in controls (p = 0.013). The deficit seen at the level of the OB did not correlate with the side of the epileptic focus. Assuming that the olfactory deficit in TLE patients is due to the central nervous epileptic focus it appears that the OB volume is not only subject to changes in the periphery of the olfactory system, but also changes as a consequence to changes at a cortical level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.