ReviewJournal of the Royal Society, Interface2013
Probing articular cartilage damage and disease by quantitative magnetic resonance imaging.
Review in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Early Imaging Biomarkers of Cartilage Strain After ACL Reconstruction Predict Patient Pain and Altered Knee Loading.Annals of biomedical engineering · 2026Article
- MRI-derived articular cartilage strains predict patient-reported outcomes six months post anterior cruciate ligament reconstruction.Scientific reports · 2025Article
- Determining the Relationship between Mechanical Properties and Quantitative Magnetic Resonance Imaging of Joint Soft Tissues Using Patient-Specific Templates.Bioengineering (Basel, Switzerland) · 2023Article
- Spatial Gradients of Quantitative MRI as Biomarkers for Early Detection of Osteoarthritis: Data From Human Explants and the Osteoarthritis Initiative.Journal of magnetic resonance imaging : JMRI · 2023Article
- Raman spectroscopy-based water measurements identify the origin of MRI T2 signal in human articular cartilage zones and predict histopathologic score.Journal of biophotonics · 2022Article
- A Useful Combination of Quantitative Ultrashort Echo Time MR Imaging and a Probing Device for Biomechanical Evaluation of Articular Cartilage.Biosensors · 2021Article
- In vivo intervertebral disc deformation: intratissue strain patterns within adjacent discs during flexion-extension.Scientific reports · 2021Article
- Combined enzymatic degradation of proteoglycans and collagen significantly alters intratissue strains in articular cartilage during cyclic compression.Journal of the mechanical behavior of biomedical materials · 2019Article
- Temporal development of near-native functional properties and correlations with qMRI in self-assembling fibrocartilage treated with exogenous lysyl oxidase homolog 2.Acta biomaterialia · 2017Article
- In Vivo Cellular Infiltration and Remodeling in a Decellularized Ovine Osteochondral Allograft.Tissue engineering. Part A · 2016Article
- In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee.Scientific reports · 2016Article
- In vivo measurement of localized tibiofemoral cartilage strains in response to dynamic activity.The American journal of sports medicine · 2015Article
- Altered swelling and ion fluxes in articular cartilage as a biomarker in osteoarthritis and joint immobilization: a computational analysis.Journal of the Royal Society, Interface · 2015Article
- T2* mapping for articular cartilage assessment: principles, current applications, and future prospects.Skeletal radiology · 2014Review
- Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics.Osteoarthritis and cartilage · 2014Review
- Simultaneous magnetic resonance imaging and consolidation measurement of articular cartilage.Sensors (Basel, Switzerland) · 2014Article
- Towards the identification of early stage osteoarthritis.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2014Review
- Near infrared spectroscopic evaluation of water in hyaline cartilage.Annals of biomedical engineering · 2013Article
- Animal models of osteoarthritis: challenges of model selection and analysis.The AAPS journal · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a debilitating disease that reflects a complex interplay of biochemical, biomechanical, metabolic and genetic factors, which are often triggered by injury, and mediated by inflammation, catabolic cytokines and enzymes. An unmet clinical need is the lack of reliable methods that are able to probe the pathogenesis of early OA when disease-rectifying therapies may be most effective. Non-invasive quantitative magnetic resonance imaging (qMRI) techniques have shown potential for characterizing the structural, biochemical and mechanical changes that occur with cartilage degeneration. In this paper, we review the background in articular cartilage and OA as it pertains to conventional MRI and qMRI techniques. We then discuss how conventional MRI and qMRI techniques are used in clinical and research environments to evaluate biochemical and mechanical changes associated with degeneration. Some qMRI techniques allow for the use of relaxometry values as indirect biomarkers for cartilage components. Direct characterization of mechanical behaviour of cartilage is possible via other specialized qMRI techniques. The combination of these qMRI techniques has the potential to fully characterize the biochemical and biomechanical states that represent the initial changes associated with cartilage degeneration. Additionally, knowledge of in vivo cartilage biochemistry and mechanical behaviour in healthy subjects and across a spectrum of osteoarthritic patients could lead to improvements in the detection, management and treatment of OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.