ArticleJournal of molecular histology2012
Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats.
Article in Journal of molecular histology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- NOSIP promotes cell proliferation and motility by targeting SPTAN1 for ubiquitination and degradation in clear cell renal cell carcinoma.Scientific reports · 2026Article
- NOSIP overexpression promotes long-term persistence of CD8Frontiers in immunology · 2026Article
- Article
- IL-1β-induces NF-κB and upregulates microRNA-372 to inhibit spinal cord injury recovery.Journal of neurophysiology · 2017Article
- Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury.Journal of molecular histology · 2014Article
- The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.PloS one · 2014Article
- Cryptochrome in sponges: a key molecule linking photoreception with phototransduction.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Up-regulation of Smurf1 after spinal cord injury in adult rats.Journal of molecular histology · 2013Article
- Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat.Journal of molecular histology · 2013Article
- Upregulation of myelin and lymphocyte protein (MAL) after traumatic spinal cord injury in rats.Journal of molecular histology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies indicated that nitric oxide (NO) is involved in secondary damage of spinal cord injury (SCI), which worsens the primary physical injury to the central nervous systems. Recently, nitric oxide synthase interacting protein (NOSIP) has been identified to interact with neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase by inhibiting the NO production. However, its expression and function after a central nervous system injury remains unclear. In this study, we examined the expression and cellular localization of NOSIP in the spinal cord of an adult rat. Western blot analysis indicated that NOSIP protein levels increased at day1 post-injury and peaked at day 14. Double immunofluorescence staining showed that NOSIP was primarily expressed in neurons and glial cells in the intact spinal cord. Interestingly, this study also showed that the expression of NOSIP significantly increased in astrocytes after injury. Furthermore, injury-induced expression of NOSIP was co-expressed with proliferating cell nuclear antigen (PCNA) positive astrocytes after injury. We also showed the NOSIP was co-localized with nNOS in gray matter and white matter after SCI. All these data taken together suggested that NOSIP may play an important roles in astrogliogenesis after a spinal cord injury.
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