ArticleStem cell research & therapy2012
Human stem cells ameliorate auditory evoked responses in a model of neuropathy.
Article in Stem cell research & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 author at 1 institution in 1 country.
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Abstract
Stem cells have been touted as a potential source of replacement cells for the treatment of severe-to-profoundly deaf individuals, including possible combined therapy with a cochlear implant. The success of such a therapy is dependent on a number of factors, but of critical importance is the functional incorporation of transplanted cells into the peripheral and central auditory systems. In a major breakthrough, Chen and colleagues recently reported the restoration of hearing thresholds by up to 46% following the transplantation of human pluripotent stem cells in a rodent auditory neuropathy model. Improved function was matched with new synapse formation in the peripheral and central aspects of the auditory system. The findings have promising clinical implications for patients with auditory neuropathy. Still to be elucidated are the long-term survival and function of transplanted cells, the precise mechanism by which hearing is restored, and whether further improvement is possible when combined with electrical stimulation from a cochlear implant.
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