ArticleMolecular oral microbiology2012
Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment.
Article in Molecular oral microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Identifying potential therapeutic targets in periodontitis: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Brazilian Organic Honeydew Reduces In Vitro and In Vivo Periodontal Disease-Related Subgingival Biofilm.Foods (Basel, Switzerland) · 2025Article
- Salivary microbiomes: a potent evidence in forensic investigations.Forensic science, medicine, and pathology · 2024Review
- Article
- Porphyromonas gingivalis outside the oral cavity.Odontology · 2022Review
- Identification of hub genes and transcription factors involved in periodontitis on the basis of multiple microarray analysis.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- Oral PathogenMicroorganisms · 2020Article
- Article
- Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality.Frontiers in immunology · 2020Review
- Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis.AMB Express · 2018Article
- Establishment of oral bacterial communities in germ-free mice and the influence of recipient age.Molecular oral microbiology · 2018Article
- Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity.Cell host & microbe · 2017Article
- Long-term evaluation of oral gavage with periodontopathogens or ligature induction of experimental periodontal disease in mice.Clinical oral investigations · 2016Article
- Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility.Journal of dental research · 2016Article
- Mitigation of Biofilm Formation on Corrugated Cardboard Fresh Produce Packaging Surfaces Using a Novel Thiazolidinedione Derivative Integrated in Acrylic Emulsion Polymers.Frontiers in microbiology · 2016Article
- Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis.Cell host & microbe · 2014Article
- Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss.Science translational medicine · 2014Article
- Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis.Molecular oral microbiology · 2013Article
- Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Microbial pathogens have evolved mechanisms to proactively manipulate innate immunity, thereby improving their fitness in mammalian hosts. We have previously shown that Porphyromonas gingivalis exploits CXC-chemokine receptor-4 (CXCR4) to instigate a subversive crosstalk with Toll-like receptor 2 that inhibits leukocyte killing of this periodontal pathogen. However, whether CXCR4 plays a role in periodontal disease pathogenesis has not been previously addressed. Here, we hypothesized that CXCR4 is required for P. gingivalis virulence in the periodontium and that treatment with AMD3100, a potent CXCR4 antagonist, would inhibit P. gingivalis-induced periodontitis. Indeed, mice given AMD3100 via osmotic minipumps became resistant to induction of periodontal bone loss following oral inoculation with P. gingivalis. AMD3100 appeared to act in an antimicrobial manner, because mice treated with AMD3100 were protected against P. gingivalis colonization and the associated elevation of the total microbiota counts in the periodontal tissue. Moreover, even when administered 2 weeks after infection, AMD3100 halted the progression of P. gingivalis-induced periodontal bone loss. Therefore, AMD3100 can act in both preventive and therapeutic ways and CXCR4 antagonism could be a promising novel approach to treat human periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.