ArticleInternational journal of radiation biology2013
Ionizing radiation causes active degradation and reduces matrix synthesis in articular cartilage.
Article in International journal of radiation biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Radiation Decreases Bone Density while Diabetes Increases Osteoarthritis in Non-Human Primates.Radiation research · 2025Article
- Articular cartilage loss is an unmitigated risk of human spaceflight.NPJ microgravity · 2024Review
- Pilot screening of potential matrikines resulting from collagen breakages through ionizing radiation.Radiation and environmental biophysics · 2024Article
- Reducing hand radiation during renal access for percutaneous nephrolithotomy: a comparison of radiation reduction techniques.Urolithiasis · 2024Article
- MakoJournal of orthopaedics · 2023Article
- Joint Cartilage in Long-Duration Spaceflight.Biomedicines · 2022Review
- Dual Characters of GH-IGF1 Signaling Pathways in Radiotherapy and Post-radiotherapy Repair of Cancers.Frontiers in cell and developmental biology · 2021Review
- Inferior and Intra-/Peri-Articular Superior Sacroiliac Joint Injection Approaches Under Ultrasound Guidance to Treat Metastasis-Related Posterior Pelvic Bone Pain.Pain practice : the official journal of World Institute of Pain · 2020Article
- Single X-ray irradiation modulates proteoglycan expression in brain tissue: investigation using mouse model.Molecular biology reports · 2020Article
- Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading.Radiation research · 2019Article
- Inflammatory disease and C-reactive protein in relation to therapeutic ionising radiation exposure in the US Radiologic Technologists.Scientific reports · 2019Article
- The effects of low-dose radiation on articular cartilage: a review.Journal of biological engineering · 2019Review
- Hemiarthroplasty for Fractures of Metastatic Bone Disease Have Different Outcomes Compared to Fractures Without Metastasis: A Matched-Pair Analysis.Surgical technology international · 2017Article
- Failed septal extension graft in a patient with a history of radiotherapy.Maxillofacial plastic and reconstructive surgery · 2016Article
- A reproducible radiation delivery method for unanesthetized rodents during periods of hind limb unloading.Life sciences in space research · 2015Article
- Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells.PloS one · 2015Article
- Total-body irradiation produces late degenerative joint damage in rats.International journal of radiation biology · 2014Article
- Effects of low dose X-ray irradiation on porcine articular cartilage explants.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeLittle is known regarding radiation effects on adult articular (joint) cartilage, though joint damage has been reported following cancer treatment or occupational exposures. The aim of this study was to determine if radiation can reduce cartilage matrix production, induce cartilage degradation, or interfere with the anabolic effects of IGF-1. MATERIALS AND
methodsIsolated chondrocytes cultured in monolayers and whole explants harvested from ankles of human donors and knees of pigs were irradiated with 2 or 10 Gy γ-rays, with or without IGF-1 stimulation. Proteoglycan synthesis and IGF-1 signaling were examined at Day 1; cartilage degradation throughout the first 96 hours.
resultsHuman and pig cartilage responded similarly to radiation. Cell viability was unchanged. Basal and IGF-1 stimulated proteoglycan synthesis was reduced following exposure, particularly following 10 Gy. Both doses decreased IGF-induced Akt activation and IGF-1 receptor phosphorylation. Matrix metalloproteinases (ADAMTS5, MMP-1, and MMP-13) and proteoglycans were released into media after 2 and 10 Gy.
conclusionsRadiation induced an active degradation of cartilage, reduced proteoglycan synthesis, and impaired IGF-1 signaling in human and pig chondrocytes. Lowered Akt activation could account for decreased matrix synthesis. Radiation may cause a functional decline of cartilage health in joints after exposure, contributing to arthropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.