Evidence map›Paper›PMID 23134048›Full record

ArticleAlcohol research : current reviews2012

Bridging Animal and Human Models: Translating From (and to) Animal Genetics.

Amanda M Barkley-Levenson, John C Crabbe

Open access · greenAbstract readEditorial
In one paragraph

Article in Alcohol research : current reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Zebrafish models of fetal alcohol spectrum disorders.Genesis (New York, N.Y. : 2000) · 2021
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Translating Alcohol Research: Opportunities and Challenges.Alcohol research : current reviews · 2015
    Review
  12. The Genetics, Neurogenetics and Pharmacogenetics of Addiction.Current behavioral neuroscience reports · 2014
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amanda M Barkley-LevensonPortland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, Oregon.
John C Crabbe
Oregon Health & Science University · US

Funding

Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Suzanne S. Fei · 2006 to 2026
$34.5M
BIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3M
Selective Breeding for Drinking in the Circadian DarkU01AA013519 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Angela Renee Ozburn · 2001 to 2026
$10.9M
NIAAA NIH HHS P60 AA010760NIAAA NIH HHS T32 AA007468NIAAA NIH HHS U01 AA013519
6 · The paper itself

Abstract

Genetics play an important role in the development and course of alcohol abuse, and understanding genetic contributions to this disorder may lead to improved preventative and therapeutic strategies in the future. Studies both in humans and in animal models are necessary to fully understand the neurobiology of alcoholism from the molecular to the cognitive level. By dissecting the complex facets of alcoholism into discrete, well-defined phenotypes that are measurable in both human populations and animal models of the disease, researchers will be better able to translate findings across species and integrate the knowledge obtained from various disciplines. Some of the key areas of alcoholism research where consilience between human and animal studies is possible are alcohol withdrawal severity, sensitivity to rewards, impulsivity, and dysregulated alcohol consumption.

Indexed as

AlcoholismDisease Models, AnimalAlcohol DrinkingAnimalsEthanolHumansPhenotypeSubstance Withdrawal SyndromeEthanol

Identifiers

PMID23134048
PMCPMC3589126
OpenAlexW1556948683

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.