ArticleAmerican journal of nuclear medicine and molecular imaging2012
Synthesis and characterization of intrinsically radiolabeled quantum dots for bimodal detection.
Article in American journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts.Cancer nanotechnology · 2023Review
- A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs.Bioinorganic chemistry and applications · 2018Review
- Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics.Advanced drug delivery reviews · 2017Review
- Vascular-targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Future Perspectives of Radionanomedicine Using the Novel Micelle-Encapsulation Method for Surface Modification.Nuclear medicine and molecular imaging · 2015Review
- The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice.Beilstein journal of nanotechnology · 2015Article
- Intrinsically radiolabeled nanoparticles: an emerging paradigm.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
- Intrinsically radiolabelled [(59)Fe]-SPIONs for dual MRI/radionuclide detection.American journal of nuclear medicine and molecular imaging · 2014Article
- Synthesis of radioactively labelled CdSe/CdS/ZnS quantum dots for in vivo experiments.Beilstein journal of nanotechnology · 2014Article
- Biomedical applications of zinc oxide nanomaterials.Current molecular medicine · 2013Review
- Quantum dot-based nanoprobes for in vivo targeted imaging.Current molecular medicine · 2013Review
- Antibody-based imaging of HER-2: moving into the clinic.Current molecular medicine · 2013Review
- Functionalized upconversion nanoparticles: versatile nanoplatforms for translational research.Current molecular medicine · 2013Review
- Pharmacokinetic issues of imaging with nanoparticles: focusing on carbon nanotubes and quantum dots.Molecular imaging and biology · 2013Review
- Graphene: a versatile nanoplatform for biomedical applications.Nanoscale · 2012Review
- In a "nutshell": intrinsically radio-labeled quantum dots.American journal of nuclear medicine and molecular imaging · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel approach was developed to synthesize radioactive quantum dots (r-QDs) thereby enabling both optical and radionuclide signals to be detected from the same intrinsic bimodal probe. This proof-of-concept is exemplified by the incorporation of the radionuclide (109)Cadmium into the core/shell of the nanoparticle. Green and near infrared (NIR) emission intrinsic r-QDs were synthesized and characterized. Zwitterionic and Poly-polyethlene glycol (PEGylated) ligands were synthesized and used to coat r-QDs. Zwitterionic NIR r-QDs (quantum yield = 11%) and PEGylated NIR r-QDs (quantum yield = 14%) with an average size of 13.8 nm and 16.8 nm were obtained respectively. The biodistribution of NIR zwitterionic and PEGylated r-QDs in nude mice was investigated and zwitterionic r-QDs showed longer blood circulation (t(1/2) = 21.4±1.1 hrs) than their PEGylated counterparts (t(1/2) = 6.4±0.5 min). Both zwitterionic and PEGylated r-QDs exhibited progressive accumulation in the liver and spleen, but the magnitude of the accumulation (%ID/g) was about 3-6 fold higher with the PEGylated r-QDs at all the time points. The results demonstrated the feasibility of r-QDs synthesis in quantitative yield and retention of fluorescence following incorporation of radioactivity into the core/shell of the nanoparticle. The gamma signal from the same fluorescent elemental material enabled quantitative and robust pharmacokinetic measurements and how these changed depended on the type of coating ligands used. This strategy for intrinsically radio-labeling the QDs is currently being implemented in our laboratory for the incorporation of other radiometals.
Indexed as
Identifiers
23133807PMC3477726W2415060693What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.