ArticlePloS one2012
High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 115 citations in OpenAlex.
- Establishing standards for genome wide association studies in eusocial insects through a case study in honey bees.Scientific reports · 2026Article
- AI-enhanced marker-assisted selection concept for the multifunctional honey bee (Hymenoptera: Apidea) protein Vitellogenin (Vg).Journal of economic entomology · 2025Article
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- Sequence-Based Multi Ancestry Association Study Reveals the Polygenic Architecture of Varroa destructor Resistance in the Honeybee Apis mellifera.Molecular ecology · 2025Article
- Avoiding the tragedies of parasite tolerance in Darwinian beekeeping.Proceedings. Biological sciences · 2025Review
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- Honey bees bred for Varroa sensitive hygiene trait demonstrate resistance to chalkbrood disease.PloS one · 2025Article
- Varroa destructor mite population dynamics in africanized honeybee (Apis mellifera) colonies in a semi-arid region.Experimental & applied acarology · 2024Review
- Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails.Nature communications · 2024Article
- Heightened sensitivity in high-grooming honey bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2024Article
- Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees.Scientific reports · 2024Article
- Epidemiology, factors influencing prevalence and level of varroosis infestation (Parasite epidemiology and control · 2023Article
- Effects of Genetic Origin of Honeybees and Climate on Prevalence and Infestation Levels of Varroa.Animals : an open access journal from MDPI · 2023Article
- Expression of Molecular Markers of Resilience againstInsects · 2023Article
- A derived honey bee stock confers resistance to Varroa destructor and associated viral transmission.Scientific reports · 2022Article
- Marker assisted selection for Varroa destructor resistance in New Zealand honey bees.PloS one · 2022Article
- Differential Expression of Three Dopamine Receptors in Varroa-Resistant Honey Bees.Journal of insect science (Online) · 2022Article
- Global similarity, and some key differences, in the metagenomes of Swedish varroa-surviving and varroa-susceptible honeybees.Scientific reports · 2021Article
- Integrated Pest Management Control of Varroa destructor (Acari: Varroidae), the Most Damaging Pest of (Apis mellifera L. (Hymenoptera: Apidae)) Colonies.Journal of insect science (Online) · 2021Review
- Comparing Survival of Israeli Acute Paralysis Virus Infection among Stocks of U.S. Honey Bees.Insects · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varroa mites (V. destructor) are a major threat to honey bees (Apis melilfera) and beekeeping worldwide and likely lead to colony decline if colonies are not treated. Most treatments involve chemical control of the mites; however, Varroa has evolved resistance to many of these miticides, leaving beekeepers with a limited number of alternatives. A non-chemical control method is highly desirable for numerous reasons including lack of chemical residues and decreased likelihood of resistance. Varroa sensitive hygiene behavior is one of two behaviors identified that are most important for controlling the growth of Varroa populations in bee hives. To identify genes influencing this trait, a study was conducted to map quantitative trait loci (QTL). Individual workers of a backcross family were observed and evaluated for their VSH behavior in a mite-infested observation hive. Bees that uncapped or removed pupae were identified. The genotypes for 1,340 informative single nucleotide polymorphisms were used to construct a high-resolution genetic map and interval mapping was used to analyze the association of the genotypes with the performance of Varroa sensitive hygiene. We identified one major QTL on chromosome 9 (LOD score = 3.21) and a suggestive QTL on chromosome 1 (LOD = 1.95). The QTL confidence interval on chromosome 9 contains the gene 'no receptor potential A' and a dopamine receptor. 'No receptor potential A' is involved in vision and olfaction in Drosophila, and dopamine signaling has been previously shown to be required for aversive olfactory learning in honey bees, which is probably necessary for identifying mites within brood cells. Further studies on these candidate genes may allow for breeding bees with this trait using marker-assisted selection.
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