ArticlePloS one2012
Reconstruction and comparison of the metabolic potential of cyanobacteria Cyanothece sp. ATCC 51142 and Synechocystis sp. PCC 6803.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
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- Natural color biofactories: advancing the spectrum of pigment production in phototrophic microbes.FEMS microbes · 2025Review
- A quantitative description of light-limited cyanobacterial growth using flux balance analysis.PLoS computational biology · 2024Article
- Elucidation of trophic interactions in an unusual single-cell nitrogen-fixing symbiosis using metabolic modeling.PLoS computational biology · 2021Article
- An integrated computational and experimental study to investigate Staphylococcus aureus metabolism.NPJ systems biology and applications · 2020Article
- OptFill: A Tool for Infeasible Cycle-Free Gapfilling of Stoichiometric Metabolic Models.iScience · 2020Article
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- Modeling the Interplay between Photosynthesis, COScientific reports · 2019Article
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- New Applications of Synthetic Biology Tools for Cyanobacterial Metabolic Engineering.Frontiers in bioengineering and biotechnology · 2019Review
- A diurnal flux balance model of Synechocystis sp. PCC 6803 metabolism.PLoS computational biology · 2019Article
- Traceability, reproducibility and wiki-exploration for "à-la-carte" reconstructions of genome-scale metabolic models.PLoS computational biology · 2018Article
- Metabolic engineering of the pentose phosphate pathway for enhanced limonene production in the cyanobacterium Synechocysti s sp. PCC 6803.Scientific reports · 2017Article
- Identifying the Metabolic Differences of a Fast-Growth Phenotype in Synechococcus UTEX 2973.Scientific reports · 2017Article
- A Comprehensively Curated Genome-Scale Two-Cell Model for the Heterocystous Cyanobacterium Anabaena sp. PCC 7120.Plant physiology · 2017Article
- Cyanobacteria as Chassis for Industrial Biotechnology: Progress and Prospects.Life (Basel, Switzerland) · 2016Review
- Article
- PSAMM: A Portable System for the Analysis of Metabolic Models.PLoS computational biology · 2016Article
- Toward Multiscale Models of Cyanobacterial Growth: A Modular Approach.Frontiers in bioengineering and biotechnology · 2016Review
- Elucidating temporal resource allocation and diurnal dynamics in phototrophic metabolism using conditional FBA.Scientific reports · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanobacteria are an important group of photoautotrophic organisms that can synthesize valuable bio-products by harnessing solar energy. They are endowed with high photosynthetic efficiencies and diverse metabolic capabilities that confer the ability to convert solar energy into a variety of biofuels and their precursors. However, less well studied are the similarities and differences in metabolism of different species of cyanobacteria as they pertain to their suitability as microbial production chassis. Here we assemble, update and compare genome-scale models (iCyt773 and iSyn731) for two phylogenetically related cyanobacterial species, namely Cyanothece sp. ATCC 51142 and Synechocystis sp. PCC 6803. All reactions are elementally and charge balanced and localized into four different intracellular compartments (i.e., periplasm, cytosol, carboxysome and thylakoid lumen) and biomass descriptions are derived based on experimental measurements. Newly added reactions absent in earlier models (266 and 322, respectively) span most metabolic pathways with an emphasis on lipid biosynthesis. All thermodynamically infeasible loops are identified and eliminated from both models. Comparisons of model predictions against gene essentiality data reveal a specificity of 0.94 (94/100) and a sensitivity of 1 (19/19) for the Synechocystis iSyn731 model. The diurnal rhythm of Cyanothece 51142 metabolism is modeled by constructing separate (light/dark) biomass equations and introducing regulatory restrictions over light and dark phases. Specific metabolic pathway differences between the two cyanobacteria alluding to different bio-production potentials are reflected in both models.
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