ArticlePloS one2012
Extracellular localization of the diterpene sclareol in clary sage (Salvia sclarea L., Lamiaceae).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Design, synthesis, and mechanistic evaluation of alepterolic acid derivatives incorporating indole and piperazine moieties as anticancer agents targeting breast cancer.Molecular diversity · 2026Article
- Review
- Sclareol Inhibit Cell Growth and Induces Apoptosis via Activation of p53/p21 Signaling Pathways in Human Oral Squamous Cell Carcinoma Cells.Journal of biochemical and molecular toxicology · 2026Article
- Identification of Endogenous Substances Involved in Sclareol-Induced Chlorophyll Reductions inPlants (Basel, Switzerland) · 2026Article
- Synthetic Biology of Sclareol: From the Plant Biosynthetic Pathway to Engineered Microbial and Photosynthetic Chassis.Biotechnology journal · 2026Review
- Critical appraisal of "unexplored limitations in the study of proximal femur fractures during the COVID-19 pandemic".Journal of bone and mineral metabolism · 2025Article
- Combinatorial metabolic engineering of Yarrowia lipolytica for high-level production of the plant-derived diterpenoid sclareol.Microbial cell factories · 2025Article
- Surgery on admission and following day reduces hip fracture complications: a Japanese DPC study.Journal of bone and mineral metabolism · 2024Article
- Phytosterols Are Involved in Sclareol-Induced Chlorophyll Reductions inPlants (Basel, Switzerland) · 2023Article
- Sclareol Inhibits Hypoxia-Inducible Factor-1α Accumulation and Induces Apoptosis in Hypoxic Cancer Cells.Advanced pharmaceutical bulletin · 2022Article
- The bioactivities of sclareol: A mini review.Frontiers in pharmacology · 2022Review
- Labdane Diterpenoids fromMolecules (Basel, Switzerland) · 2021Article
- Characterization and evolutionary analysis of Cucumber mosaic virus isolate infecting3 Biotech · 2021Article
- Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway.Horticulture research · 2021Article
- Therapeutic Potential of Sclareol in Experimental Models of Rheumatoid Arthritis.International journal of molecular sciences · 2018Article
- The Diterpene Sclareol Vascular Effect in Normotensive and Hypertensive Rats.Arquivos brasileiros de cardiologia · 2017Article
- Localization of a defensive volatile 4-hydroxy-4-methylpentan-2-one in the capitate glandular trichomes ofPlant diversity · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sclareol is a high-value natural product obtained by solid/liquid extraction of clary sage (Salvia sclarea L.) inflorescences. Because processes of excretion and accumulation of this labdane diterpene are unknown, the aim of this work was to gain knowledge on its sites of accumulation in planta. Samples were collected in natura or during different steps of the industrial process of extraction (steam distillation and solid/liquid extraction). Samples were then analysed with a combination of complementary analytical techniques (gas chromatography coupled to a mass spectrometer, polarized light microscopy, environmental scanning electron microscopy, two-photon fluorescence microscopy, second harmonic generation microscopy). According to the literature, it is hypothesized that sclareol is localized in oil pockets of secretory trichomes. This study demonstrates that this is not the case and that sclareol accumulates in a crystalline epicuticular form, mostly on calyces.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.