ArticlePloS one2012
Differential evolution of MAGE genes based on expression pattern and selection pressure.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Evolutionary and Expression Analysis of the Pig MAGE Gene Family.Animals : an open access journal from MDPI · 2024Article
- TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth.EMBO reports · 2024Article
- Emerging roles of the MAGE protein family in stress response pathways.The Journal of biological chemistry · 2020Review
- Downregulation of Brain Enriched Type 2 MAGEs Is Associated With Immune Infiltration and Poor Prognosis in Glioma.Frontiers in oncology · 2020Article
- Genome-wide profiling of mRNA and lncRNA expression in dengue fever and dengue hemorrhagic fever.FEBS open bio · 2019Article
- Dynamic Copy Number Evolution of X- and Y-Linked Ampliconic Genes in Human Populations.Genetics · 2018Article
- Evolution of Melanoma Antigen-A11 (MAGEA11) During Primate Phylogeny.Journal of molecular evolution · 2018Article
- Cellular and disease functions of the Prader-Willi Syndrome geneThe Biochemical journal · 2017Review
- A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases.Journal of molecular biology · 2017Review
- High expression levels of MAGE-A9 are correlated with unfavorable survival in lung adenocarcinoma.Oncotarget · 2016Article
- Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.PloS one · 2016Article
- A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels.BMC evolutionary biology · 2015Article
- The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.Cell cycle (Georgetown, Tex.) · 2015Article
- Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats.PLoS genetics · 2014Article
- Demethylation of CpG islands in the 5' upstream regions mediates the expression of the human testis-specific gene MAGEB16 and its mouse homolog Mageb16.BMB reports · 2014Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Starting from publicly-accessible datasets, we have utilized comparative and phylogenetic genome analyses to characterize the evolution of the human MAGE gene family. Our characterization of genomic structures in representative genomes of primates, rodents, carnivora, and macroscelidea indicates that both Type I and Type II MAGE genes have undergone lineage-specific evolution. The restricted expression pattern in germ cells of Type I MAGE orthologs is observed throughout evolutionary history. Unlike Type II MAGEs that have conserved promoter sequences, Type I MAGEs lack promoter conservation, suggesting that epigenetic regulation is a central mechanism for controlling their expression. Codon analysis shows that Type I but not Type II MAGE genes have been under positive selection. The combination of genomic and expression analysis suggests that Type 1 MAGE promoters and genes continue to evolve in the hominin lineage, perhaps towards functional diversification or acquiring additional specific functions, and that selection pressure at codon level is associated with expression spectrum.
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