ArticleKorean journal of pediatrics2012
Renal scar formation after urinary tract infection in children.
Article in Korean journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Antimicrobial resistance in Africa: a systematic review.BMC infectious diseases · 2017Pooled it
- Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial.Pediatric nephrology (Berlin, Germany) · 2022Trial
- Prevalence and Clinical Features of Vesicoureteral Reflux in Children With Recurrent Urinary Tract Infections: A Cross-Sectional Study.Health science reports · 2026Article
- Pathogenesis and Immunomodulation of Urinary Tract Infections Caused by UropathogenicMicroorganisms · 2025Review
- Genetic determinants of renal scarring in children with febrile UTI.Pediatric nephrology (Berlin, Germany) · 2024Article
- A Comparison of Outcomes from Antibiotic Treatment with and without Probiotics in 897 Patients with Lower Urogenital Tract Infections, Including Cystitis, Urethritis, Prostatitis, and Vulvovaginitis.Medical science monitor basic research · 2024Article
- Urinary neutrophil gelatinase-associated lipocalin: a marker of urinary tract infection among febrile children.Clinical and experimental pediatrics · 2021Article
- Management of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?Frontiers in pediatrics · 2021Review
- Renal scarring following urinary tract infections in children.Sudanese journal of paediatrics · 2019Article
- Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Renal Parenchymal Involvement in Infants With Febrile Urinary Tract Infection: A Preliminary Study.Annals of laboratory medicine · 2018Article
- Antimicrobial misuse in pediatric urinary tract infections: recurrences and renal scarring.Annals of clinical microbiology and antimicrobials · 2018Article
- A critical review of recent clinical practice guidelines for pediatric urinary tract infection.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Prevalence and antimicrobial sensitivity pattern of urinary tract infection among children with cerebral palsy, Moshi, Tanzania.Pediatric health, medicine and therapeutics · 2018Article
- Inflammation drives renal scarring in experimental pyelonephritis.American journal of physiology. Renal physiology · 2017Article
- Molecular typing of uropathogenic Escherichia coli isolated from Korean children with urinary tract infection.Korean journal of pediatrics · 2015Article
- Long-term risk of renal impairment after complete primary repair of classic bladder exstrophy.Urology annalsArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary tract infection (UTI) is a common bacterial illness in children. Acute pyelonephritis in children may lead to renal scarring with the risk of later hypertension, preeclampsia during pregnancy, proteinuria, and renal insufficiency. Until now, vesicoureteral reflux (VUR) has been considered the most important risk factor for post-UTI renal scar formation in children. VUR predisposes children with UTI to pyelonephritis, and both are associated with renal scarring. However, reflux nephropathy is not always acquired; rather, it reflects reflux-associated congenital dysplastic kidneys. The viewpoint that chronic kidney disease results from renal maldevelopment-associated VUR has led to questioning the utility of any regimen directed at identifying or treating VUR. Despite the recognition that underlying renal anomalies may be the cause of renal scarring that was previously attributed to infection, the prevention of renal scarring remains the goal of all therapies for childhood UTI. Therefore, children at high risk of renal scar formation after UTI should be treated and investigated until a large clinical study and basic research give us more information.
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Registered trials
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