ArticleFrontiers in synaptic neuroscience2012
Homer1 gene products orchestrate Ca(2+)-permeable AMPA receptor distribution and LTP expression.
Article in Frontiers in synaptic neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- The noncoding circular RNAiScience · 2025Article
- Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Hyaluronidase-induced matrix remodeling contributes to long-term synaptic changes.Frontiers in neural circuits · 2024Article
- Remembering and forgetting in sleep: Selective synaptic plasticity during sleep driven by scaling factors Homer1a and Arc.Neurobiology of stress · 2023Article
- Opposite Regulation of Homer Signal at the NMJ Postsynaptic Micro Domain between Slow- and Fast-Twitch Muscles in an Experimentally Induced Autoimmune Myasthenia Gravis (EAMG) Mouse Model.International journal of molecular sciences · 2022Article
- Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions.Neural regeneration research · 2022Review
- Microglia maintain the normal structure and function of the hippocampal astrocyte network.Glia · 2022Article
- The Complex Formed by Group I Metabotropic Glutamate Receptor (mGluR) and Homer1a Plays a Central Role in Metaplasticity and Homeostatic Synaptic Scaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Liraglutide preconditioning attenuates myocardial ischemia/ reperfusion injury via homer1 activation.Aging · 2021Article
- Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity.Molecular neuropsychiatry · 2019Review
- Impaired Cognitive Function and Altered Hippocampal Synaptic Plasticity in Mice Lacking Dermatan Sulfotransferase Chst14/D4st1.Frontiers in molecular neuroscience · 2019Article
- The Role of Polyamine-Dependent Facilitation of Calcium Permeable AMPARs in Short-Term Synaptic Enhancement.Frontiers in cellular neuroscience · 2018Review
- Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning.Neural plasticity · 2017Article
- Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment.Molecular autism · 2016Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the role of Homer1 gene products on the presence of synaptic Ca(2+)-permeable AMPA receptors (AMPARs) and long-term potentiation (LTP) generation in hippocampal CA1 pyramidal neurons, using mice either lacking all Homer1 isoforms (Homer1 KO) or overexpressing the immediate early gene (IEG) product Homer1a (H1aTG). We found that Homer1 KO caused a significant redistribution of the AMPAR subunit GluA2 from the dendritic compartment to the soma. Furthermore, deletion of Homer1 enhanced the AMPAR-mediated component of glutamatergic currents at Schaffer collateral synapses as demonstrated by increased AMPA/NMDA current ratios. Meanwhile, LTP generation appeared to be unaffected. Conversely, sustained overexpression of Homer1a strongly reduced AMPA/NMDA current ratios and polyamine sensitivity of synaptic AMPAR, indicating that the proportion of synaptic GluA2-containing AMPAR increased relative to WT. LTP maintenance was abolished in H1aTG. Notably, overexpression of Homer1a in Homer1 KO or GluA2 KO mice did not affect LTP expression, suggesting activity-dependent interaction between Homer1a and long Homer1 isoforms with GluA2-containing AMPAR. Thus, Homer1a is essential for the activity-dependent regulation of excitatory synaptic transmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.