ArticlePLoS genetics2012
Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Review
- Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis.Journal of ovarian research · 2025Article
- Article
- Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation.Calcified tissue international · 2024Article
- Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color.Nature communications · 2024Article
- Cis-regulatory control of mammalian Trps1 gene expression.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans.Nature genetics · 2024Article
- Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs.PloS one · 2024Article
- Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip.PeerJ · 2024Article
- TRPS1 regulates the opposite effect of progesterone via RANKL in endometrial carcinoma and breast carcinoma.Cell death discovery · 2023Article
- TRPS1: A Marker of Follicular Differentiation.Dermatopathology (Basel, Switzerland) · 2023Article
- Article
- A Missense Mutation inAnnals of dermatology · 2022Article
- Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing.Cell stem cell · 2022Article
- Review
- Atlas of Prenatal Hair Follicle Morphogenesis Using the Pig as a Model System.Frontiers in cell and developmental biology · 2021Article
- Genetic Signatures of Selection for Cashmere Traits in Chinese Goats.Animals : an open access journal from MDPI · 2020Article
- TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development.Genes & development · 2020Article
- Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells.Frontiers in cell and developmental biology · 2020Article
- Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells.Molecular genetics and metabolism · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hereditary hypertrichoses are a group of hair overgrowth syndromes that are extremely rare in humans. We have previously demonstrated that a position effect on TRPS1 is associated with hypertrichosis in humans and mice. To gain insight into the functional role of Trps1, we analyzed the late morphogenesis vibrissae phenotype of Trps1(Δgt) mutant mice, which is characterized by follicle degeneration after peg downgrowth has been initiated. We found that Trps1 directly represses expression of the hair follicle stem cell regulator Sox9 to control proliferation of the follicle epithelium. Furthermore, we identified a copy number variation upstream of SOX9 in a family with hypertrichosis that significantly decreases expression of the gene in the hair follicle, providing new insights into the long-range regulation of SOX9. Our findings uncover a novel transcriptional hierarchy that regulates epithelial proliferation in the developing hair follicle and contributes to the pathology of hypertrichosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.