ArticlePLoS genetics2012
Morphogenesis and cell fate determination within the adaxial cell equivalence group of the zebrafish myotome.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- The challenges of using fish cells for cultivated seafood production.Food science and biotechnology · 2025Review
- Learning Latent Trajectories in Developmental Time Series with Hidden-Markov Optimal Transport.bioRxiv : the preprint server for biology · 2025Article
- Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.Development (Cambridge, England) · 2023Article
- Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology.Marine biotechnology (New York, N.Y.) · 2023Review
- NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration.Nature communications · 2021Article
- atoh8 expression pattern in early zebrafish embryonic development.Histochemistry and cell biology · 2021Article
- Evolution of Somite Compartmentalization: A View FromFrontiers in cell and developmental biology · 2021Article
- Pro-resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates.British journal of pharmacology · 2020Article
- Shaping the zebrafish myotome by intertissue friction and active stress.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Developmental Phases of Zebrafish Myogenesis.Journal of developmental biology · 2019Review
- TNF signaling and macrophages govern fin regeneration in zebrafish larvae.Cell death & disease · 2017Article
- Fgf regulates dedifferentiation during skeletal muscle regeneration in adult zebrafish.Cellular signalling · 2016Article
- Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish.Development (Cambridge, England) · 2016Article
- Slow Muscle Precursors Lay Down a Collagen XV Matrix Fingerprint to Guide Motor Axon Navigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.Developmental biology · 2015Article
- Article
- Hanging on for the ride: adhesion to the extracellular matrix mediates cellular responses in skeletal muscle morphogenesis and disease.Developmental biology · 2015Review
- Sample drift correction following 4D confocal time-lapse imaging.Journal of visualized experiments : JoVE · 2014Article
- The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.Developmental biology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
One of the central questions of developmental biology is how cells of equivalent potential-an equivalence group-come to adopt specific cellular fates. In this study we have used a combination of live imaging, single cell lineage analyses, and perturbation of specific signaling pathways to dissect the specification of the adaxial cells of the zebrafish embryo. We show that the adaxial cells are myogenic precursors that form a cell fate equivalence group of approximately 20 cells that consequently give rise to two distinct sub-types of muscle fibers: the superficial slow muscle fibers (SSFs) and muscle pioneer cells (MPs), distinguished by specific gene expression and cell behaviors. Using a combination of live imaging, retrospective and indicative fate mapping, and genetic studies, we show that MP and SSF precursors segregate at the beginning of segmentation and that they arise from distinct regions along the anterior-posterior (AP) and dorsal-ventral (DV) axes of the adaxial cell compartment. FGF signaling restricts MP cell fate in the anterior-most adaxial cells in each somite, while BMP signaling restricts this fate to the middle of the DV axis. Thus our results reveal that the synergistic actions of HH, FGF, and BMP signaling independently create a three-dimensional (3D) signaling milieu that coordinates cell fate within the adaxial cell equivalence group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.