ArticlePLoS genetics2012
Comparative genomics suggests an independent origin of cytoplasmic incompatibility in Cardinium hertigii.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 152 citations in OpenAlex.
- Diversity ofInternational journal of molecular sciences · 2026Article
- Comparative Genomics of the Endosymbiont Cardinium Causing Reproductive Manipulation in Encarsia Parasitoid Wasps.MicrobiologyOpen · 2025Article
- Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility.Biochemical Society transactions · 2025Review
- Male-dependent resistance toRoyal Society open science · 2025Article
- Elucidating the Molecular Mechanisms of Sex Ratio Distortion Mediated by Cytoplasmic Symbionts.Genome biology and evolution · 2025Review
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- A novelmSphere · 2025Article
- The ecology, evolution, and physiology of Cardinium: a widespread heritable endosymbiont of invertebrates.FEMS microbiology reviews · 2025Review
- Limited Variation in Bacterial Communities ofInsects · 2024Article
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- Egg provisioning explains the penetrance of symbiont-mediated sex allocation distortion in haplodiploids.Heredity · 2023Article
- Complete De Novo Assembly ofInternational journal of molecular sciences · 2023Article
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- Distribution of Bacterial Endosymbionts of theInternational journal of molecular sciences · 2023Article
- A Novel Widespread MITE Element in the Repeat-Rich Genome of theMicrobiology spectrum · 2022Article
- Phylogenetic reconciliation.PLoS computational biology · 2022Article
- Genome sequencing and comparative analysis of Wolbachia strain wAlbA reveals Wolbachia-associated plasmids are common.PLoS genetics · 2022Article
- Highly transmissible cytoplasmic incompatibility by the extracellular insect symbiontiScience · 2022Article
- Endosymbionts moderate constrained sex allocation in a haplodiploid thrips species in a temperature-sensitive way.Heredity · 2022Article
- Quality over quantity: unraveling the contributions to cytoplasmic incompatibility caused by two coinfecting Cardinium symbionts.Heredity · 2022Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Terrestrial arthropods are commonly infected with maternally inherited bacterial symbionts that cause cytoplasmic incompatibility (CI). In CI, the outcome of crosses between symbiont-infected males and uninfected females is reproductive failure, increasing the relative fitness of infected females and leading to spread of the symbiont in the host population. CI symbionts have profound impacts on host genetic structure and ecology and may lead to speciation and the rapid evolution of sex determination systems. Cardinium hertigii, a member of the Bacteroidetes and symbiont of the parasitic wasp Encarsia pergandiella, is the only known bacterium other than the Alphaproteobacteria Wolbachia to cause CI. Here we report the genome sequence of Cardinium hertigii cEper1. Comparison with the genomes of CI-inducing Wolbachia pipientis strains wMel, wRi, and wPip provides a unique opportunity to pinpoint shared proteins mediating host cell interaction, including some candidate proteins for CI that have not previously been investigated. The genome of Cardinium lacks all major biosynthetic pathways but harbors a complete biotin biosynthesis pathway, suggesting a potential role for Cardinium in host nutrition. Cardinium lacks known protein secretion systems but encodes a putative phage-derived secretion system distantly related to the antifeeding prophage of the entomopathogen Serratia entomophila. Lastly, while Cardinium and Wolbachia genomes show only a functional overlap of proteins, they show no evidence of laterally transferred elements that would suggest common ancestry of CI in both lineages. Instead, comparative genomics suggests an independent evolution of CI in Cardinium and Wolbachia and provides a novel context for understanding the mechanistic basis of CI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.