ArticlePLoS pathogens2012
Circulating virus load determines the size of bottlenecks in viral populations progressing within a host.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
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- Novel program for automatic calculation of EPG variables.Journal of insect science (Online) · 2024Article
- Vector acquisition and co-inoculation of two plant viruses influences transmission, infection, and replication in new hosts.Scientific reports · 2022Article
- A plant virus satellite RNA directly accelerates wing formation in its insect vector for spread.Nature communications · 2021Article
- Genetic evidence for the involvement of Dicer-like 2 and 4 as well as Argonaute 2 in theThe Journal of general virology · 2021Article
- VERSO: A comprehensive framework for the inference of robust phylogenies and the quantification of intra-host genomic diversity of viral samples.Patterns (New York, N.Y.) · 2021Article
- Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity.iScience · 2021Article
- Virus titre determines the efficiency ofVirusdisease · 2018Article
- A deadly dance: the choreography of host-pathogen interactions, as revealed by single-cell technologies.Nature communications · 2018Review
- Comment on "Large Bottleneck Size in Cauliflower Mosaic Virus Populations during Host Plant Colonization" by Monsion et al. (2008).PLoS pathogens · 2016Article
- Genetic variation in fitness within a clonal population of a plant RNA virus.Virus evolution · 2016Article
- The Multiplicity of Cellular Infection Changes Depending on the Route of Cell Infection in a Plant Virus.Journal of virology · 2015Article
- Demographics of natural oral infection of mosquitos by Venezuelan equine encephalitis virus.Journal of virology · 2015Article
- Analysis of viral (zucchini yellow mosaic virus) genetic diversity during systemic movement through a Cucurbita pepo vine.Virus research · 2014Article
- Within-host spatiotemporal dynamics of plant virus infection at the cellular level.PLoS genetics · 2014Article
- Population bottlenecks during the infectious cycle of the Lyme disease spirochete Borrelia burgdorferi.PloS one · 2014Article
- Narrow bottlenecks affect Pea seedborne mosaic virus populations during vertical seed transmission but not during leaf colonization.PLoS pathogens · 2014Article
- Zucchini yellow mosaic virus (ZYMV, Potyvirus): vertical transmission, seed infection and cryptic infections.Virus research · 2013Article
- Viral and cellular factors involved in Phloem transport of plant viruses.Frontiers in plant science · 2013Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For any organism, population size, and fluctuations thereof, are of primary importance in determining the forces driving its evolution. This is particularly true for viruses--rapidly evolving entities that form populations with transient and explosive expansions alternating with phases of migration, resulting in strong population bottlenecks and associated founder effects that increase genetic drift. A typical illustration of this pattern is the progression of viral disease within a eukaryotic host, where such demographic fluctuations are a key factor in the emergence of new variants with altered virulence. Viruses initiate replication in one or only a few infection foci, then move through the vasculature to seed secondary infection sites and so invade distant organs and tissues. Founder effects during this within-host colonization might depend on the concentration of infectious units accumulating and circulating in the vasculature, as this represents the infection dose reaching new organs or "territories". Surprisingly, whether or not the easily measurable circulating (plasma) virus load directly drives the size of population bottlenecks during host colonization has not been documented in animal viruses, while in plants the virus load within the sap has never been estimated. Here, we address this important question by monitoring both the virus concentration flowing in host plant sap, and the number of viral genomes founding the population in each successive new leaf. Our results clearly indicate that the concentration of circulating viruses directly determines the size of bottlenecks, which hence controls founder effects and effective population size during disease progression within a host.
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