ArticlePLoS pathogens2012
A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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Who cites it
47 citing papers in PubMed, 66 citations in OpenAlex.
- Autonomous intranasal delivery systems for central nervous system therapeutics.Experimental & molecular medicine · 2026Review
- The Role of Enoxaparin in Influenza Virus Infections and its Therapeutic Implications.The Journal of infectious diseases · 2026Article
- Transcriptomic landscape of pseudorabies virus-induced encephalitis reveals key lncRNAs involved in host-neurotropic virus interactions.Veterinary research · 2025Article
- Olfactory immunology: the missing piece in airway and CNS defence.Nature reviews. Immunology · 2024Review
- Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy.Nature communications · 2024Article
- Indirect CD4Journal of virology · 2024Article
- Antiviral Functions of Type I and Type III Interferons in the Olfactory Epithelium.Biomolecules · 2023Article
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- Recent Advancements in Understanding Primary Cytomegalovirus Infection in a Mouse Model.Viruses · 2022Review
- Intranasal drug delivery: opportunities and toxicologic challenges during drug development.Drug delivery and translational research · 2022Review
- Pathogenic Exploitation of Lymphatic Vessels.Cells · 2022Review
- Olfactory Entry Promotes Herpesvirus Recombination.Journal of virology · 2021Article
- A Live Olfactory Mouse Cytomegalovirus Vaccine, Attenuated for Systemic Spread, Protects against Superinfection.Journal of virology · 2021Article
- Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives.Journal of virology · 2021Article
- SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain.iScience · 2020Article
- The Role of Herpes Simplex Virus Type 1 Infection in Demyelination of the Central Nervous System.International journal of molecular sciences · 2020Review
- Immune Control ofViral immunology · 2020Article
- The role of motile cilia in the development and physiology of the nervous system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- A CD4Journal of virology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Herpesviruses are ubiquitous pathogens that cause much disease. The difficulty of clearing their established infections makes host entry an important target for control. However, while herpesviruses have been studied extensively in vitro, how they cross differentiated mucus-covered epithelia in vivo is unclear. To establish general principles we tracked host entry by Murid Herpesvirus-4 (MuHV-4), a lymphotropic rhadinovirus related to the Kaposi's Sarcoma-associated Herpesvirus. Spontaneously acquired virions targeted the olfactory neuroepithelium. Like many herpesviruses, MuHV-4 binds to heparan sulfate (HS), and virions unable to bind HS showed poor host entry. While the respiratory epithelium expressed only basolateral HS and was bound poorly by incoming virions, the neuroepithelium also displayed HS on its apical neuronal cilia and was bound strongly. Incoming virions tracked down the neuronal cilia, and either infected neurons or reached the underlying microvilli of the adjacent glial (sustentacular) cells and infected them. Thus the olfactory neuroepithelium provides an important and complex site of HS-dependent herpesvirus uptake.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.