ArticleAmerican journal of epidemiology2012
Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.
Article in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association Between Maternal Factors and Risk of Congenital Heart Disease in Offspring: A Systematic Review and Meta-Analysis.Maternal and child health journal · 2023Pooled it
- Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes.American journal of epidemiology · 2017Pooled it
- Prenatal Surgery for Open Fetal Spina Bifida in Patients with Obesity: A Review of Current Evidence and Future Directions.Journal of clinical medicine · 2024Review
- Contribution of obesity to racial and ethnic disparities in the risk of fetal myelomeningocele: a population-based study.AJOG global reports · 2024Article
- Gene-nutrient interactions that impact magnesium homeostasis increase risk for neural tube defects in mice exposed to dolutegravir.Frontiers in cell and developmental biology · 2023Article
- Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure.WIREs mechanisms of disease · 2022Review
- Identification of the Key Regulators of Spina Bifida Through Graph-Theoretical Approach.Frontiers in genetics · 2021Article
- [Association of maternal diabetes mellitus and UCP2 gene polymorphisms with congenital heart disease in offspring: a case-control study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Fetal Acrania (Exencephaly) in the Context of a Pregnant Female Taking Adalimumab for Psoriasis: A Case Report.Biologics : targets & therapy · 2020Article
- Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects.PloS one · 2020Article
- Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data.Birth defects research · 2019Article
- Genetic epidemiology of neural tube defects.Journal of pediatric rehabilitation medicine · 2017Review
- Impact of sample collection participation on the validity of estimated measures of association in the National Birth Defects Prevention Study when assessing gene-environment interactions.Genetic epidemiology · 2017Article
- Population-based case-control study of the association between weather-related extreme heat events and neural tube defects.Birth defects research · 2017Article
- Genetic association of the glycine cleavage system genes and myelomeningocele.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
- Detecting gene-environment interactions in human birth defects: Study designs and statistical methods.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- Association of facilitated glucose transporter 2 gene variants with the myelomeningocele phenotype.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- Genome-wide association study of maternal and inherited effects on left-sided cardiac malformations.Human molecular genetics · 2015Article
- Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.BMC medical genetics · 2014Article
- Risk of birth defects associated with maternal pregestational diabetes.European journal of epidemiology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study during 1999-2007. Log-linear models were used to evaluate maternal and offspring genetic effects. After application of the false discovery rate, there were 5 significant maternal genetic effects. The less common alleles at the 4 FTO single nucleotide polymorphisms showed a reduction of NTD risk (for rs1421085, relative risk (RR) = 0.73 (95% confidence interval (CI): 0.62, 0.87); for rs8050136, RR = 0.79 (95% CI: 0.67, 0.93); for rs9939609, RR = 0.79 (95% CI: 0.67, 0.94); and for rs17187449, RR = 0.80 (95% CI: 0.68, 0.95)). Additionally, maternal LEP rs2071045 (RR = 1.31, 95% CI: 1.08, 1.60) and offspring UCP2 rs660339 (RR = 1.32, 95% CI: 1.06, 1.64) were associated with NTD risk. Furthermore, the maternal genotype for TCF7L2 rs3814573 suggested an increased NTD risk among obese women. These findings indicate that maternal genetic variants associated with glucose homeostasis may modify the risk of having an NTD-affected pregnancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.