ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Effects of the BDNF Val66Met polymorphism on white matter microstructure in healthy adults.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder.Behavioural neurology · 2021Pooled it
- Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits.Molecular psychiatry · 2022Article
- Structural and functional thalamocortical connectivity study in female fibromyalgia.Scientific reports · 2021Article
- Preliminary Evidence of Improvement in Adolescent and Young Adult Cancer Survivors' Brain Health Following Physical Activity: A Proof-of-Concept Sub-Study.Brain plasticity (Amsterdam, Netherlands) · 2021Article
- Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.Scientific reports · 2020Article
- Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations.Psychiatry investigation · 2020Article
- Dissociation of BDNF Val66Met polymorphism on neurocognitive functioning in military veterans with and without a history of remote mild traumatic brain injury.The Clinical neuropsychologist · 2020Article
- Newborn white matter microstructure moderates the association between maternal postpartum depressive symptoms and infant negative reactivity.Social cognitive and affective neuroscience · 2020Article
- Cerebral white matter diffusion properties and free-water with obstructive sleep apnea severity in older adults.Human brain mapping · 2020Article
- TheBrain sciences · 2020Review
- Article
- Effects of BDNF ValNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- White matter integrity alterations in post-traumatic stress disorder.Human brain mapping · 2018Article
- Cognition, serum BDNF levels, and BDNF Val66Met polymorphism in type 2 diabetes patients and healthy controls.Oncotarget · 2018Article
- BDNF ValNeuroImage · 2017Article
- The BDNF ValBehavioural brain research · 2017Article
- The association of sleep and physical activity with integrity of white matter microstructure in bipolar disorder patients and healthy controls.Psychiatry research. Neuroimaging · 2017Article
- The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression.European archives of psychiatry and clinical neuroscience · 2017Article
- The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network.Frontiers in human neuroscience · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The BDNF Val(66)Met polymorphism, a possible risk variant for mental disorders, is a potent modulator of neural plasticity in humans and has been linked to deficits in gray matter structure, function, and cognition. The impact of the variant on brain white matter structure, however, is controversial and remains poorly understood. Here, we used diffusion tensor imaging to examine the effects of BDNF Val(66)Met genotype on white matter microstructure in a sample of 85 healthy Caucasian adults. We demonstrate decreases of fractional anisotropy and widespread increases in radial diffusivity in Val/Val homozygotes compared with Met-allele carriers, particularly in prefrontal and occipital pathways. These data provide an independent confirmation of prior imaging genetics work, are consistent with complex effects of the BDNF Val(66)Met polymorphism on human brain structure, and may serve to generate hypotheses about variation in white matter microstructure in mental disorders associated with this variant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.