ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
A dual point-of-care test shows good performance in simultaneously detecting nontreponemal and treponemal antibodies in patients with syphilis: a multisite evaluation study in China.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.Sexually transmitted infections · 2022Pooled it
- The impact of antenatal syphilis point of care testing on pregnancy outcomes: A systematic review.PloS one · 2021Pooled it
- Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Pooled it
- Evaluating the MedMira Multiplo® Complete Syphilis (TP/nTP) antibody test in a sexually transmitted infection clinic in Ottawa, Canada: increased rapid diagnosis and improved antibiotic stewardship.BMC infectious diseases · 2025Trial
- How to Use Rapid Dual Treponemal and Lipoidal Tests in Clinical Practice.Sexually transmitted diseases · 2026Article
- Opportunities to Optimize Outcomes of Diagnosis and Treatment of HIV and Syphilis in Pregnancy: the Quest to Eliminate Maternal and Vertical Transmission.Current HIV/AIDS reports · 2025Review
- Laboratory Evaluation of the Chembio DPP Syphilis Screen & Confirm Point-of-Care Test on Serum and Simulated Blood Samples.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- Rapid Serologic Test for Diagnosis of Yaws in Patients with Suspicious Skin Ulcers.Emerging infectious diseases · 2023Article
- Laboratory Evaluation of the DPP Syphilis Screen & Confirm Assay.Microbiology spectrum · 2022Article
- Stopping syphilis transmission in Arctic communities through rapid diagnostic testing: The STAR study protocol.PloS one · 2022Article
- Diagnosing point-of-care diagnostics for neglected tropical diseases.PLoS neglected tropical diseases · 2021Review
- Novel Diagnostics for Kaposi Sarcoma and Other Skin Diseases in Resource-Limited Settings.Dermatologic clinics · 2021Review
- Nanotechnology in reproductive medicine: Opportunities for clinical translation.Clinical and experimental reproductive medicine · 2020Article
- Syphilis Self-testing: A Nationwide Pragmatic Study Among Men Who Have Sex With Men in China.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso.Sexually transmitted infections · 2019Article
- Evaluation of the utility of a rapid test for syphilis at a sexually transmitted disease clinic in Buenos Aires, Argentina.Scientific reports · 2018Article
- Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.PLoS neglected tropical diseases · 2018Article
- Syphilis.Nature reviews. Disease primers · 2017Review
- Syphilis: Re-emergence of an old foe.Microbial cell (Graz, Austria) · 2016Review
- Review
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid point-of-care (POC) syphilis tests based on simultaneous detection of treponemal and nontreponemal antibodies (dual POC tests) offer the opportunity to increase coverage of syphilis screening and treatment. This study aimed to conduct a multisite performance evaluation of a dual POC syphilis test in China.
methodsParticipants were recruited from patients at sexually transmitted infection clinics and high-risk groups in outreach settings in 6 sites in China. Three kinds of specimens (whole blood [WB], fingerprick blood [FB], and blood plasma [BP]) were used for evaluating sensitivity and specificity of the Dual Path Platform (DPP) Syphilis Screen and Confirm test using its treponemal and nontreponemal lines to compare Treponema pallidum particle agglutination (TPPA) assay and toluidine red unheated serum test (TRUST) as reference standards.
resultsA total of 3134 specimens (WB 1323, FB 488, and BP 1323) from 1323 individuals were collected. The sensitivities as compared with TPPA were 96.7% for WB, 96.4% for FB, and 94.6% for BP, and the specificities were 99.3%, 99.1%, and 99.6%, respectively. The sensitivities as compared with TRUST were 87.2% for WB, 85.8% for FB, and 88.4% for BP, and the specificities were 94.4%, 96.1%, and 95.0%, respectively. For specimens with a TRUST titer of 1:4 or higher, the sensitivities were 100.0% for WB, 97.8% for FB, and 99.6% for BP.
conclusionsDPP test shows good sensitivity and specificity in detecting treponemal and nontreponemal antibodies in 3 kinds of specimens. It is hoped that this assay can be considered as an alternative in the diagnosis of syphilis, particularly in resource-limited areas.
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