ArticleCerebral cortex (New York, N.Y. : 1991)2014
Developmental origin of patchy axonal connectivity in the neocortex: a computational model.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Preparation of surgical meshes using self-regulating technology based on reaction-diffusion processes.Medical & biological engineering & computing · 2024Article
- Calibration of stochastic, agent-based neuron growth models with approximate Bayesian computation.Journal of mathematical biology · 2024Article
- Retinal waves in adaptive rewiring networks orchestrate convergence and divergence in the visual system.Network neuroscience (Cambridge, Mass.) · 2024Article
- Unification of free energy minimization, spatiotemporal energy, and dimension reduction models of V1 organization: Postnatal learning on an antenatal scaffold.Frontiers in computational neuroscience · 2022Article
- Modular Organization of Signal Transmission in Primate Somatosensory Cortex.Frontiers in neuroanatomy · 2022Article
- Creative Destruction: A Basic Computational Model of Cortical Layer Formation.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- A generative growth model for thalamocortical axonal branching in primary visual cortex.PLoS computational biology · 2020Article
- Article
- Multi-phasic bi-directional chemotactic responses of the growth cone.Scientific reports · 2016Article
- A Computational Model of Innate Directional Selectivity Refined by Visual Experience.Scientific reports · 2015Article
- Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue.Brain structure & function · 2015Article
- A hybrid computational model to predict chemotactic guidance of growth cones.Scientific reports · 2015Article
- Developmental self-construction and -configuration of functional neocortical neuronal networks.PLoS computational biology · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injections of neural tracers into many mammalian neocortical areas reveal a common patchy motif of clustered axonal projections. We studied in simulation a mathematical model for neuronal development in order to investigate how this patchy connectivity could arise in layer II/III of the neocortex. In our model, individual neurons of this layer expressed the activator-inhibitor components of a Gierer-Meinhardt reaction-diffusion system. The resultant steady-state reaction-diffusion pattern across the neuronal population was approximately hexagonal. Growth cones at the tips of extending axons used the various morphogens secreted by intrapatch neurons as guidance cues to direct their growth and invoke axonal arborization, so yielding a patchy distribution of arborization across the entire layer II/III. We found that adjustment of a single parameter yields the intriguing linear relationship between average patch diameter and interpatch spacing that has been observed experimentally over many cortical areas and species. We conclude that a simple Gierer-Meinhardt system expressed by the neurons of the developing neocortex is sufficient to explain the patterns of clustered connectivity observed experimentally.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.