ArticleGenome medicine2012
Going back to the future with Guthrie-powered epigenome-wide association studies.
Article in Genome medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Article
- Assessment of dried blood spots for DNA methylation profiling.Wellcome open research · 2019Article
- Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation.Clinical epigenetics · 2018Article
- Thymus activity measured by T-cell receptor excision circles in patients with different severities of respiratory syncytial virus infection.BMC infectious diseases · 2017Article
- Neonatal Levels of T-cell Receptor Excision Circles (TREC) in Patients with 22q11.2 Deletion Syndrome and Later Disease Features.Journal of clinical immunology · 2015Article
- The Role of Epigenetic Change in Autism Spectrum Disorders.Frontiers in neurology · 2015Review
- DNA methylation biomarkers: cancer and beyond.Genes · 2014Review
- Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling.BMC biotechnology · 2014Article
- Study protocol: the Childhood to Adolescence Transition Study (CATS).BMC pediatrics · 2013Article
- The use of DNA from archival dried blood spots with the Infinium HumanMethylation450 array.BMC biotechnology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenome-wide association studies (EWAS) can be used to investigate links between early life environment, epigenetics and disease. However, such studies raise the question of which came first: the mark or the malady? A recent study has demonstrated that EWAS can be performed on neonatal 'Guthrie' heel-prick blood spots. As Guthrie cards are collected from all newborn infants and stored indefinitely in many countries, they represent an important timepoint to compare with later disease-associated epigenetic marks.
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Registered trials
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