ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2012
A combined index of structure and function for staging glaucomatous damage.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optical coherence tomography for glaucoma diagnosis: An evidence based meta-analysis.PloS one · 2018Pooled it
- Retinal Ganglion Cell Degeneration in Glaucoma: Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Novel Structure-Function Models for Estimating Retinal Ganglion Cell Count Using Pattern Electroretinography in Glaucoma Suspects.Diagnostics (Basel, Switzerland) · 2025Article
- Associations between retinal thickness and background factors in eyes without retinal diseases.Scientific reports · 2025Article
- Biomarkers for the Progression of Intermediate Age-Related Macular Degeneration.Ophthalmology and therapy · 2023Review
- Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids.Scientific reports · 2023Article
- Ganglion Cell Complex Analysis: Correlations with Retinal Nerve Fiber Layer on Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2023Review
- Structure-function models for estimating retinal ganglion cell count using steady-state pattern electroretinography and optical coherence tomography in glaucoma suspects and preperimetric glaucoma: an electrophysiological pilot study.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Time-Frequency Analysis of ERG With Discrete Wavelet Transform and Matching Pursuits for Glaucoma.Translational vision science & technology · 2022Article
- Test of a Retinal Nerve Fiber Bundle Trajectory Model Using Eyes With Glaucomatous Optic Neuropathy.Translational vision science & technology · 2022Article
- Quantifying biomarkers of axonal degeneration in early glaucoma to find the disc at risk.Scientific reports · 2022Article
- Contrast-to-Noise Ratios to Evaluate the Detection of Glaucomatous Progression in the Superior and Inferior Hemiretina.Translational vision science & technology · 2022Article
- Blood Pressure and Glaucomatous Progression in a Large Clinical Population.Ophthalmology · 2022Article
- Prediction of glaucoma severity using parameters from the electroretinogram.Scientific reports · 2021Article
- Global Glaucoma Staging System (GGSS): A New Method to Simultaneously Assess the Severity of Both Functional and Structural Damage in Glaucoma.Journal of clinical medicine · 2021Article
- A simplified combined index of structure and function for detecting and staging glaucomatous damage.Scientific reports · 2021Article
- Impact of Intraocular Pressure Control on Rates of Retinal Nerve Fiber Layer Loss in a Large Clinical Population.Ophthalmology · 2021Article
- Evaluation of Macular and Retinal Ganglion Cell Count Estimates for Detecting and Staging Glaucoma.Frontiers in medicine · 2021Article
- Characterizing and quantifying the temporal relationship between structural and functional change in glaucoma.PloS one · 2021Article
- Clinical Perspectives and Trends: Microperimetry as a Trial Endpoint in Retinal Disease.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2021Review
11 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage.
methodsObservational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects. All the eyes were tested with standard automated perimetry and spectral domain optical coherence tomography within 6 months. Estimates of the number of retinal ganglion cells (RGCs) were obtained from standardautomated perimetry and spectral domain optical coherence tomography and a weighted averaging scheme was used to obtain a final estimate of the number of RGCs for each eye. The CSFI was calculated as the percent loss of RGCs obtained by subtracting estimated from expected RGC numbers. The performance of the CSFI for discriminating glaucoma from normal eyes and the different stages of disease was evaluated by receiver operating characteristic curves.
resultsThe mean CSFI, representing the mean estimated percent loss of RGCs, was 41% and 17% in the perimetric and preperimetric groups, respectively (P.001). They were both significantly higher than the mean CSFI in the healthy group (P.001). The CSFI had larger receiver operating characteristic curve areas than isolated indexes of structure and function for detecting perimetric and preperimetric glaucoma and differentiating among early, moderate, and advanced stages of visual field loss.
conclusionAn index combining structure and function performed better than isolated structural and functional measures for detection of perimetric and preperimetric glaucoma as well as for discriminating different stages of the disease.
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