ArticlePulmonary circulation2012
Pulmonary blood flow and pulmonary hypertension: Is the pulmonary circulation flowophobic or flowophilic?
Article in Pulmonary circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Shear stress unveils patient-specific transcriptional signatures in PAH: Towards personalized molecular diagnostics.Theranostics · 2025Article
- Neurohormonal activation pattern in patients with atrial septal defect.Scientific reports · 2024Article
- Application of a modified clinical classification for pulmonary arterial hypertension associated with congenital heart disease in children: emphasis on atrial septal defects and transposition of the great arteries. An analysis from the TOPP registry.Frontiers in cardiovascular medicine · 2024Article
- Down syndrome child with multiple heart diseases: A case report.World journal of cardiology · 2023Article
- Clinical and echocardiographic findings in patients with COVID-19 across different severity levels.Journal of medicine and life · 2023Article
- A pneumonectomy model to study flow-induced pulmonary hypertension and compensatory lung growth.Cell reports methods · 2023Article
- Pulmonary vascular disease as a complication of pediatric congenital heart diseases.Translational pediatrics · 2023Review
- Maldevelopment of the Immature Pulmonary Vasculature and Prolonged Patency of the Ductus Arteriosus: Association or Cause?American journal of respiratory and critical care medicine · 2023Article
- Partial anomalous pulmonary venous return in adults: Insight into pulmonary hypertension.International journal of cardiology. Congenital heart disease · 2023Article
- Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation.Pulmonary circulation · 2022Article
- Computational simulation-derived hemodynamic and biomechanical properties of the pulmonary arterial tree early in the course of ventricular septal defects.Biomechanics and modeling in mechanobiology · 2021Article
- Evaluation and Management of Pulmonary Arterial Hypertension in Congenital Heart Disease.Methodist DeBakey cardiovascular journal · 2021Review
- Adult congenital heart disease with pulmonary arterial hypertension: mechanisms and management.Heart failure reviews · 2020Review
- Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.JACC. Basic to translational science · 2018Article
- Pulmonary hypertension's variegated landscape: a snapshot.Pulmonary circulation · 2017Review
- Right Ventricular Outflow Tract Velocity Time Integral Determination in 570 Healthy Children and in 52 Pediatric Atrial Septal Defect Patients.Pediatric cardiology · 2015Article
- Pulmonary hypertension caused by pulmonary venous hypertension.Pulmonary circulation · 2014Review
- Diverse forms of pulmonary hypertension remodel the arterial tree to a high shear phenotype.American journal of physiology. Heart and circulatory physiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased pulmonary blood flow (PBF) is widely thought to provoke pulmonary vascular obstructive disease (PVO), but the impact of wall shear stress in the lung is actually poorly defined. We examined information from patients having cardiac lesions which impact the pulmonary circulation in distinct ways, as well as experimental studies, asking how altered hemodynamics impact the risk of developing PVO. Our results are as follows: (1) with atrial septal defect (ASD; increased PBF but low PAP), shear stress may be increased but there is little tendency to develop PVO; (2) with normal PBF but increased pulmonary vascular resistance (PVR; mitral valve disease) shear stress may also be increased but risk of PVO still low; (3) with high PVR and PBF (e.g., large ventricular septal defect), wall shear stress is markedly increased and the likelihood of developing PVO is much higher than with high PBF or PAP only; and (4) with ASD, experimental and clinical observations suggest that increased PBF plus another stimulus (e.g., endothelial inflammation) may be required for PVO. We conclude that modestly increased wall shear stress (e.g., ASD) infrequently provokes PVO, and likely requires other factors to be harmful. Likewise, increased PAP seldom causes PVO. Markedly increased wall shear stress may greatly increase the likelihood of PVO, but we cannot discriminate its effect from the combined effects of increased PAP and PBF. Finally, the age of onset of increased PAP may critically impact the risk of PVO. Some implications of these observations for future investigations are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.