ArticleFrontiers in neural circuits2012
A computational model of inferior colliculus responses to amplitude modulated sounds in young and aged rats.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat.Aging brain · 2026Article
- Age-related ultrastructural differences in the dorsal cortex of the inferior colliculus in the fischer brown Norway rat.Neurobiology of aging · 2026Article
- Ultrastructural characterization of neuropeptide Y synapses in the central inferior colliculus of the Fischer Brown Norway rat.Neuropeptides · 2025Article
- Ultrastructural Synaptic Differences in the Central Inferior Colliculus in the 3xTG Mouse Across Three Disease Stages.The Journal of comparative neurology · 2025Article
- Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat.Neurobiology of aging · 2025Article
- Article
- Expression of group II mGluRs in the inferior colliculus, medial geniculate body, and auditory cortex increases with age.Neuroscience · 2025Article
- Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats.Frontiers in aging neuroscience · 2025Article
- Practical Bayesian Inference in Neuroscience: Or How I Learned to Stop Worrying and Embrace the Distribution.eNeuro · 2024Article
- Neurometric amplitude modulation detection in the inferior colliculus of Young and Aged rats.Hearing research · 2024Article
- Practical Bayesian Inference in Neuroscience: Or How I Learned To Stop Worrying and Embrace the Distribution.bioRxiv : the preprint server for biology · 2024Article
- Age-related Changes of GAD1 mRNA Expression in the Central Inferior Colliculus.Translational medicine of aging · 2023Article
- Age-related ultrastructural changes in the lateral cortex of the inferior colliculus.Neurobiology of aging · 2022Article
- Longitudinal auditory pathophysiology following mild blast-induced trauma.Journal of neurophysiology · 2021Article
- Hearing loss and brain plasticity: the hyperactivity phenomenon.Brain structure & function · 2021Review
- Objective evidence of temporal processing deficits in older adults.Hearing research · 2020Review
- Temporal Coding of Single Auditory Nerve Fibers Is Not Degraded in Aging Gerbils.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability?Brain sciences · 2019Review
- Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation.Neuroscience · 2019Review
- Aging alters envelope representations of speech-like sounds in the inferior colliculus.Neurobiology of aging · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The inferior colliculus (IC) receives ascending excitatory and inhibitory inputs from multiple sources, but how these auditory inputs converge to generate IC spike patterns is poorly understood. Simulating patterns of in vivo spike train data from cellular and synaptic models creates a powerful framework to identify factors that contribute to changes in IC responses, such as those resulting in age-related loss of temporal processing. A conductance-based single neuron IC model was constructed, and its responses were compared to those observed during in vivo IC recordings in rats. IC spike patterns were evoked using amplitude-modulated tone or noise carriers at 20-40 dB above threshold and were classified as low-pass, band-pass, band-reject, all-pass, or complex based on their rate modulation transfer function tuning shape. Their temporal modulation transfer functions were also measured. These spike patterns provided experimental measures of rate, vector strength, and firing pattern for comparison with model outputs. Patterns of excitatory and inhibitory synaptic convergence to IC neurons were based on anatomical studies and generalized input tuning for modulation frequency. Responses of modeled ascending inputs were derived from experimental data from previous studies. Adapting and sustained IC intrinsic models were created, with adaptation created via calcium-activated potassium currents. Short-term synaptic plasticity was incorporated into the model in the form of synaptic depression, which was shown to have a substantial effect on the magnitude and time course of the IC response. The most commonly observed IC response sub-types were recreated and enabled dissociation of inherited response properties from those that were generated in IC. Furthermore, the model was used to make predictions about the consequences of reduction in inhibition for age-related loss of temporal processing due to a reduction in GABA seen anatomically with age.
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