ArticleInternational journal of mass spectrometry2012
Increasing the Trapping Mass Range to m/z = 10(9)-A Major Step Toward High Resolution Mass Analysis of Intact RNA, DNA and Viruses.
Article in International journal of mass spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- The FUNPET-a New Hybrid Ion Funnel-Ion Carpet Atmospheric Pressure Interface for the Simultaneous Transmission of a Broad Mass Range.Journal of the American Society for Mass Spectrometry · 2018Article
- Digital Waveform Technology and the Next Generation of Mass Spectrometers.Journal of the American Society for Mass Spectrometry · 2018Article
- On the Fine Isotopic Distribution and Limits to Resolution in Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- MS/MS networking guided analysis of molecule and gene cluster families.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This work demonstrates sampling of singly-charged particles up to 200 nm in diameter at atmospheric pressure into vacuum and trapping large numbers (>10(6)) at a point in front of the end cap electrode of a linear quadrupole ion guide/trap for on-demand injection into the acceleration region of a time-of-flight mass spectrometer in a well-collimated ion packet. This procedure was shown to yield trapping efficiencies that ranged from 4-5 percent for 10 nm diameter urea particles (~ 400 kDa) to 1 percent for 200 nm urea particles (~ 3 × 10(9) Da). Analysis of the inlet optimization procedure suggests that the inlet can be adapted to sample and trap beyond the 200 nm range. Review of the most likely places for ion loss in the sampling process suggests that the sampling and trapping efficiencies can be improved well beyond the 4-5 percent shown. Moreover, it suggests that sampling of smaller than 10 nm ions could achieve efficiencies in the 10's of percent range thereby suggesting new levels of sensitivity can be achieved for small ions (< 200 kDa). Finally, demonstration of trapping large numbers of 200 nm (3 × 10(9) Da) ions for on-demand ejection in well collimated temporally discrete ion packets is a prelude to resolved mass analysis in that range.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.