ArticleProceedings of the National Academy of Sciences of the United States of America2012
Bone morphogenetic protein- and mating-dependent secretory cell growth and migration in the Drosophila accessory gland.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Phylogenetic Relatedness Does not Predict Patterns of Parallel Transcriptome Adaptation in Drosophila.Genome biology and evolution · 2025Article
- Oncogenic signaling in the Drosophila prostate-like accessory gland activates a pro-tumorigenic program in the absence of proliferation.Disease models & mechanisms · 2025Article
- Male-derived transcripts isolated from the mated female reproductive tract in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Transcriptional programs are activated and microRNAs are repressed within minutes after mating in the Drosophila melanogaster female reproductive tract.BMC genomics · 2023Article
- Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.PLoS genetics · 2023Article
- Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation.Journal of extracellular vesicles · 2023Article
- Recovery from heat-induced infertility-A study of reproductive tissue responses and fitness consequences in maleEcology and evolution · 2022Article
- Single-nucleus transcriptomes reveal evolutionary and functional properties of cell types in the Drosophila accessory gland.Genetics · 2022Article
- Developmental expression patterns of toolkit genes in male accessory gland of Drosophila parallels those of mammalian prostate.Biology open · 2021Article
- ThePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Regulation of Body Size and Growth Control.Genetics · 2020Review
- Glutamine deprivation alters the origin and function of cancer cell exosomes.The EMBO journal · 2020Article
- Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- BMP signaling inhibition inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mating induces switch from hormone-dependent to hormone-independent steroid receptor-mediated growth in Drosophila secondary cells.PLoS biology · 2019Article
- Proteins, Transcripts, and Genetic Architecture of Seminal Fluid and Sperm in the MosquitoMolecular & cellular proteomics : MCP · 2019Article
- Physiological and Environmental Factors Affecting the Composition of the Ejaculate in Mosquitoes and Other Insects.Insects · 2019Review
- Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity.Traffic (Copenhagen, Denmark) · 2019Article
- The impact of ageing on male reproductive success in Drosophila melanogaster.Experimental gerontology · 2018Article
- The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies.Current topics in developmental biology · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The paired male accessory glands of Drosophila melanogaster enhance sperm function, stimulate egg production, and reduce female receptivity to other males by releasing a complex mixture of glycoproteins from a secretory epithelium into seminal fluid. A small subpopulation of about 40 specialized secretory cells, called secondary cells, resides at the distal tip of each gland. We show that these cells grow via mechanisms promoted by mating. If aging males mate repeatedly, a subset of these cells delaminates from and migrates along the apical surface of the glandular epithelium toward the proximal end of the gland. Remarkably, these secretory cells can transfer to females with sperm during mating. The frequency of this event increases with age, so that more than 50% of triple-mated, 18-d-old males transfer secondary cells to females. Bone morphogenetic protein signaling specifically in secondary cells is needed to drive all of these processes and is required for the accessory gland to produce its normal effects on female postmating behavior in multiply mated males. We conclude that secondary cells are secretory cells with unusual migratory properties that can allow them to be transferred to females, and that these properties are a consequence of signaling that is required for secondary cells to maintain their normal reproductive functions as males age and mate.
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