ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2013
Surgical pathway and management of pineal region tumours in children.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Biopsy of Pineal Tumors: Endoscopy or Stereotaxic or Neuronavigation Guided?Advances and technical standards in neurosurgery · 2026Pooled it
- Neoadjuvant chemotherapy for pineal region tumors.Journal of neuro-oncology · 2026Article
- Pineal Tumours: Results, Follow-Up and Sequelae in Children and Adults According to the French Registry of Pineal Tumours and the Lyonnais Registry.Advances and technical standards in neurosurgery · 2026Article
- Supracerebellar highway-fast and safe road to pediatric pineal tumor resection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Machine learning decision support model construction for craniotomy approach of pineal region tumors based on MRI images.BMC medical imaging · 2025Article
- Purely Endoscopic Supracerebellar Infratentorial Approach to the Pineal Region in Pediatric Population.Advances and technical standards in neurosurgery · 2024Article
- Machine learning-based classification of pineal germinoma from magnetic resonance imaging.World neurosurgery: X · 2023Article
- Neuroendoscopy in the management of pineal region tumours in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Results of the treatment of pineal tumors in children: the Lyon experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Neck Pain and Headache After Pinealectomy: Improvement with Multimodal Chiropractic Therapies.The American journal of case reports · 2022Article
- Evaluation of the Perioperative and Postoperative Course of Surgery for Pineal Germinoma in the SIOP CNS GCT 96 Trial.Cancers · 2022Article
- Management of pineal region tumors in a pediatric case series.Neurosurgical review · 2021Article
- Continuum Robot With Follow-the-Leader Motion for Endoscopic Third Ventriculostomy and Tumor Biopsy.IEEE transactions on bio-medical engineering · 2020Article
- Determining an Optimal Cutoff of Serum β-Human Chorionic Gonadotropin for Assisting the Diagnosis of Intracranial Germinomas.PloS one · 2016Article
- Common molecularcytogenetic alterations in tumors originating from the pineal region.Oncology letters · 2015Article
- Neuroendoscopic biopsy of pediatric brain tumors with small ventricle.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Endoscopic biopsy of brain tumors: Does the technique matter?Surgical neurology international · 2014Review
- Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications.Neuro-oncology · 2013Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPineal region tumours are rare. Surgery is associated with high morbidity, and consensus on ideal management pathways remains variable.
methodPatients with pineal region tumours were identified from the neuro-oncology database, and their data were retrospectively reviewed. Data collection included presentation, germ cell markers, tumour size and location, imaging, histology, treatment and control/relapse rates.
resultsTwenty-four patients were treated at Alder Hey Children's Hospital between 1998 and 2010. Median age at diagnosis was 12.7 years. Sixteen patients presented with hydrocephalus. Twelve were successfully treated with endoscopic third ventriculostomy (EVT), and four required shunt insertion during follow-up. Fifteen patients had endoscopic biopsies. Eleven biopsies were performed at the same time as third ventriculostomy, and four patients without significant hydrocephalus had endoscopic image-guided biopsies. Eight patients had stereotactic biopsies (either because of slit ventricles at diagnosis or because of a ventriculoperitoneal shunt already in place), and only one patient had an open biopsy. No morbidity or mortality was associated with the biopsies. Histology showed four pineal parenchymal tumours, nine gliomas and eleven germ cell tumours. Thirteen patients underwent surgical resection. Significant tumour debulking was achieved in all of these patients, with gross total resection in 70 % of cases. There was one intraventricular haemorrhage (full recovery) and one mild hemiparesis. There was no surgical mortality.
conclusionThe mainstay of hydrocephalus management is EVT which provides a safe and reliable route for biopsy. In our experience, craniotomy and tumour resection are effective and safe.
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