Evidence map›Paper›PMID 23129407›Full record

ArticleThe Prostate2013

Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice.

Christopher M Jackson, Dallas B Flies, Claudio A Mosse, Anil Parwani, Edward L Hipkiss, Charles G Drake

Abstract read
In one paragraph

Article in The Prostate, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Antagonists of growth hormone-releasing hormone inhibit proliferation induced by inflammation in prostatic epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Christopher M JacksonDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dallas B Flies
Claudio A Mosse
Anil Parwani
Edward L Hipkiss
Charles G Drake
Johns Hopkins Medicine · USJohns Hopkins University · USPennsylvania State University · USShadyside Hospital · USVA Tennessee Valley Healthcare System · USYale University · US

Funding

TRANSGENIC MODELS FOR PROSTATE CANCER AND AUTOIMMUNITYP50CA058236 · NCI · JOHNS HOPKINS UNIVERSITY · PI ISAACS, JOHN TOD · 1992 to 2020
$43.9M
Analysis of Lag-3 in Regulatory T Cell Function and Immune SupressionR01CA127153 · NCI · JOHNS HOPKINS UNIVERSITY · PI DRAKE, CHARLES G. · 2008 to 2012
$1.7M
NCI NIH HHS 1P50CA58236-15NCI NIH HHS P50 CA058236NCI NIH HHS R01 CA127153
6 · The paper itself

Abstract

backgroundProstatitis, a clinical syndrome characterized by pelvic pain and inflammation, is common in adult males. Although several induced and spontaneous murine models of prostatitis have been explored, the role of genetic background on induction has not been well-defined.

methodsUsing a standard methodology for the induction of experimental autoimmune prostatitis (EAP), we investigated both acute and chronic inflammation on several murine genetic backgrounds.

resultsIn our colony, nonobese diabetic (NOD) mice evinced spontaneous prostatitis that was not augmented by immunization with rat prostate extract (RPE). In contrast, the standard laboratory strain Balb/c developed chronic inflammation in response to RPE immunization. Development of EAP in other strains was variable.

conclusionsThese data suggest that Balb/c mice injected with RPE may provide a useful model for chronic prostatic inflammation.

Indexed as

Autoimmune DiseasesDisease Models, AnimalMice, Inbred BALB CProstatitisAcute DiseaseAnimalsAutoimmunityCell ExtractsChronic DiseaseMaleMiceMice, Inbred C57BLMice, Inbred MRL lprMice, Inbred NODMice, Inbred NZBProstateCell Extracts

Identifiers

PMID23129407
PMCPMC3618623
OpenAlexW2045719585

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.