ArticleEuropean journal of applied physiology2013
Low total haemoglobin mass, blood volume and aerobic capacity in men with type 1 diabetes.
Article in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The relationship between hemoglobin andPloS one · 2023Pooled it
- The Oxygen Transport Cascade During Maximal-Intensity Exercise in Uncomplicated Type 1 Diabetes: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2026Review
- Physically active adults with uncomplicated type 1 diabetes exhibit normal cardiopulmonary exercise test responses versus healthy controls.Physiological reports · 2026Article
- Association between glycated haemoglobin ADiabetes, obesity & metabolism · 2025Article
- A method for determination of hematocrit using the mobile app "HaemoCalc": Validity, reliability, and effect of user expertise.Physiological reports · 2025Article
- The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes.Diabetologia · 2024Article
- Impaired erythropoietin response to hypoxia in type 2 diabetes.Acta diabetologica · 2024Article
- Cardiopulmonary exercise testing before and after intravenous iron in preoperative patients: a prospective clinical study.Perioperative medicine (London, England) · 2023Article
- Association of HbA1c with VOMetabolites · 2022Review
- Altered Expiratory Flow Dynamics at Peak Exercise in Adult Men With Well-Controlled Type 1 Diabetes.Frontiers in physiology · 2022Article
- Anti-Diabetic and Antioxidant Activities of Red Wine Concentrate Enriched with Polyphenol Compounds under Experimental Diabetes in Rats.Antioxidants (Basel, Switzerland) · 2021Article
- Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning.International journal of molecular sciences · 2020Review
- Application of the optimized carbon monoxide rebreathing method for the measurement of total haemoglobin mass in chronic liver disease.Physiological reports · 2020Article
- Replicating measurements of total hemoglobin mass (tHb-mass) within a single day: precision of measurement; feasibility and safety of using oxygen to expedite carbon monoxide clearance.Physiological reports · 2018Article
- Consequences of Type 1 and 2 Diabetes Mellitus on the Cardiovascular Regulation During Exercise: A Brief Review.Current diabetes reviews · 2017Review
- Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia.Haematologica · 2017Observational
- Resting heart rate variability and exercise capacity in Type 1 diabetes.Physiological reports · 2017Article
- Haemoglobin concentration and mass as determinants of exercise performance and of surgical outcome.Extreme physiology & medicine · 2013Article
- Body temperature regulation in diabetes.Temperature (Austin, Tex.)Review
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8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Blood O₂ carrying capacity affects aerobic capacity (VO₂max). Patients with type 1 diabetes have a risk for anaemia along with renal impairment, and they often have low VO₂max. We investigated whether total haemoglobin mass (tHb-mass) and blood volume (BV) differ in men with type 1 diabetes (T1D, n = 12) presently without complications and in healthy men (CON, n = 23) (age-, anthropometry-, physical activity-matched), to seek an explanation for low VO₂max. We determined tHb-mass, BV, haemoglobin concentration ([Hb]), and VO₂max in T1D and CON. With similar (mean ± SD) [Hb] (144 vs. 145 g l(-1)), T1D had lower tHb-mass (10.1 ± 1.4 vs. 11.0 ± 1.1 g kg(-1), P < 0.05), BV (76.8 ± 9.5 vs. 83.5 ± 8.3 ml kg(-1), P < 0.05) and VO₂max (35.4 ± 4.8 vs. 44.9 ± 7.5 ml kg(-1) min(-1), P < 0.001) than CON. VO₂max correlated with tHb-mass and BV both in T1D (r = 0.71, P < 0.01 and 0.67, P < 0.05, respectively) and CON (r = 0.54, P < 0.01 and 0.66, P < 0.001, respectively), but not with [Hb]. Linear regression slopes were shallower in T1D than CON both between VO₂max and tHb-mass (2.4 and 3.6 ml kg(-1) min(-1) vs. g kg(-1), respectively) and VO₂max and BV (0.3 and 0.6 ml kg(-1) min(-1) vs. g kg(-1), respectively), indicating that T1D were unable to reach similar VO₂max than CON at a given tHb-mass and BV. In conclusion, low tHb-mass and BV partly explained low VO₂max in T1D and may provide early and more sensitive markers of blood O₂ carrying capacity than [Hb] alone.
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