Evidence map›Paper›PMID 23128427›Full record

Trial reportJAMA neurology2013

Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease.

Lisa M Shulman, Leslie I Katzel, Frederick M Ivey, John D Sorkin, Knachelle Favors, Karen E Anderson, Barbara A Smith, Stephen G Reich, William J Weiner, Richard F Macko

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 157 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 23 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03517371 nacompletednot on this mapstarted 2019, after this paper: background citation

Walking and mHealth to Increase Participation in Parkinson Disease

TypeinterventionalSponsorBoston University Charles River CampusRan2019 to 2024Enrolled140ConditionsParkinson DiseaseArmsmHealth delivered exercise program, Exercise only
NCT04251728 nacompletednot on this mapstarted 2022, after this paper: background citation

Chronic Effects of Automated Mechanical Peripheral Stimulation on Cardiovascular and Functional Variables in Patients With Parkinson's Disease

TypeinterventionalSponsorUniversidad Católica del MauleRan2022 to 2022Enrolled40ConditionsParkinson DiseaseArmsAutomated mechanical peripheral stimulation, Physical Exercise, SHAM
NCT06246747 nacompletednot on this mapstarted 2020, after this paper: background citation

The Use of Telerehabilitation to Improve Movement-related Outcomes and Quality of Life for Patients With Parkinson's Disease: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorWizecareRan2020 to 2023Enrolled19ConditionsParkinson DiseaseArmsIn clinic physical therapy, Telerehabilitation only
NCT06324422 narecruitingnot on this mapstarted 2024, after this paper: background citation

Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?

TypeinterventionalSponsorUniversity of AarhusRan2024 to 2026Enrolled94ConditionsParkinson's DiseaseArmsAerobic exercise intervention, Resistance exercise intervention
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 23 syntheses or guidelines pooled it, 407 citations in OpenAlex.

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  11. Guideline
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  15. Current Perspectives on Aerobic Exercise in People with Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
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  20. Treadmill training for patients with Parkinson's disease.The Cochrane database of systematic reviews · 2015
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lisa M ShulmanUniversity of Maryland School of Medicine, Department of Neurology, Baltimore,MD21201, USA. lshulman@som.umaryland.edu
Leslie I Katzel
Frederick M Ivey
John D Sorkin
Knachelle Favors
Karen E Anderson
Barbara A Smith
Stephen G Reich
William J Weiner
Richard F Macko
University of Maryland, Baltimore · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Cardiovascular Disease Mechanisms in HIV Infected and Uninfected VeteransR01HL095136 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREIBERG, MATTHEW S, JUSTICE, AMY CAROLINE · 2008 to 2012
$5.6M
HANDLS Scan Substudy: Race, Socioeconomic status, and the BrainR01AG034161 · NIA · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI WALDSTEIN, SHARI · 2009 to 2013
$2.8M
Development and Validation of a Self-Efficacy Item BankU01AR057967 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULMAN, LISA M. · 2009 to 2012
$2.5M
The Biology of Exercise, Metabolism and AgingT32AG000219 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI RYAN, ALICE S. · 1992 to 2014
$2.4M
Exercise training and cognitive and physical function in CKDR01DK090401 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI SELIGER, STEPHEN L., WEINER, DANIEL E · 2011 to 2014
$2.3M
CLINICAL RESEARCH CURRICULM AWARDK30HL004518 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MORRIS, JOHN GLENN · 2000 to 2004
$995k
NHLBI NIH HHS K30 HL004518NHLBI NIH HHS R01 HL095136NIAMS NIH HHS U01 AR057967NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG034161NIA NIH HHS T32 AG000219NIDDK NIH HHS R01 DK090401
6 · The paper itself

Abstract

objectiveTo compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease.

designA comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise.

settingThe Parkinson's Disease and Movement Disorders Center at the University of Maryland and the Baltimore Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center. PATIENTS: A total of 67 patients with Parkinson disease who had gait impairment were randomly assigned to 1 of 3 arms of the trial. INTERVENTIONS; (1) A higher-intensity treadmill exercise (30 minutes at 70%-80% of heart rate reserve), (2) a lower-intensity treadmill exercise (50 minutes at 40%-50% of heart rate reserve), and (3) stretching and resistance exercises (2 sets of 10 repetitions on each leg on 3 resistance machines [leg press, leg extension, and curl]). These exercises were performed 3 times a week for 3 months.

main outcome measuresThe primary outcome measures were gait speed (6-minute walk), cardiovascular fitness (peak oxygen consumption per unit time [$$ VO2], and muscle strength (1-repetition maximum strength).

resultsAll 3 types of physical exercise improved distance on the 6-minute walk: lower-intensity treadmill exercise (12% increase; P=.001), stretching and resistance exercises (9% increase; P<.02), and higher-intensity treadmill exercise (6% increase; P=.07), with no between-group differences. Both treadmill exercises improved peak $$ VO2 (7%-8% increase; P<.05) more than did the stretching and resistance exercises. Only stretching and resistance improved muscle strength (16% increase; P<.001).

conclusionsThe effects of exercise were seen across all 3 exercise groups. The lower-intensity treadmill exercise resulted in the greatest improvement in gait speed. Both the higher- and lower-intensity treadmill exercises improved cardiovascular fitness. Only the stretching and resistance exercises improved muscle strength. Therefore, exercise can improve gait speed, muscle strength, and fitness for patients with Parkinson disease. The combination of treadmill and resistance exercises may result in greater benefit and requires further investigation.

Indexed as

AdultAgedElectrocardiographyExerciseExercise TestFemaleGaitHumansMaleMiddle AgedMuscle Stretching ExercisesParkinson DiseaseProspective StudiesResistance TrainingSingle-Blind Method

Identifiers

PMID23128427
PMCPMC4574905
OpenAlexW2124808208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.