ArticleThe Journal of cell biology2012
Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Polarity protein Par3 deficiency promotes metastasis of bladder cancer via interaction of Ppp1r12c.Biology direct · 2026Article
- PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity.Cellular and molecular life sciences : CMLS · 2023Article
- Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion.Cancer gene therapy · 2023Article
- Identification and characterization of Crumbs polarity complex proteins in Caenorhabditis elegans.The Journal of biological chemistry · 2022Article
- Circulative Transmission of Cileviruses inFrontiers in microbiology · 2022Article
- Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes.Cellular and molecular life sciences : CMLS · 2021Article
- Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke.Neuropsychiatric disease and treatment · 2021Review
- Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized.The Journal of cell biology · 2020Article
- Mitochondrial morphology and activity regulate furrow ingression and contractile ring dynamics inMolecular biology of the cell · 2020Article
- Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.The Journal of cell biology · 2019Article
- Redundant regulation of localization and protein stability of DmPar3.Cellular and molecular life sciences : CMLS · 2018Article
- Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes.Cellular and molecular life sciences : CMLS · 2017Article
- Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis ineLife · 2017Article
- Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.Nature communications · 2017Article
- Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms.The Journal of cell biology · 2017Article
- Domain-specific functions of Stardust inRoyal Society open science · 2016Article
- Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- A self-organized biomechanical network drives shape changes during tissue morphogenesis.Nature · 2015Article
- Localization and Function of Pals1-associated Tight Junction Protein in Drosophila Is Regulated by Two Distinct Apical Complexes.The Journal of biological chemistry · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The assembly and consolidation of the adherens junctions (AJs) are key events in the establishment of an intact epithelium. However, AJs are further modified to obtain flexibility for cell migration and morphogenetic movements. Intact AJs in turn are a prerequisite for the establishment and maintenance of apical-basal polarity in epithelial cells. In this study, we report that the conserved PDZ (PSD95, Discs large, ZO-1) domain-containing protein PATJ (Pals1-associated tight junction protein) was not per se crucial for the maintenance of apical-basal polarity in Drosophila melanogaster epithelial cells but rather regulated Myosin localization and phosphorylation. PATJ directly bound to the Myosin-binding subunit of Myosin phosphatase and decreased Myosin dephosphorylation, resulting in activated Myosin. Thereby, PATJ supports the stability of the Zonula Adherens. Notably, weakening of AJ in a PATJ mutant epithelium led first to a loss of Myosin from the AJ, subsequently to a disassembly of the AJ, and finally, to a loss of apical-basal polarity and disruption of the tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.