ArticleRespiratory physiology & neurobiology2013
Airway-parenchymal interdependence in the lung slice.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- High throughput screening of airway constriction in mouse lung slices.Scientific reports · 2024Article
- Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery.Respiratory research · 2024Review
- Perspectives on precision cut lung slices-powerful tools for investigation of mechanisms and therapeutic targets in lung diseases.Frontiers in pharmacology · 2023Review
- Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- Article
- Dynamics of airway response in lung microsections: a tool for studying airway-extra cellular matrix interactions.Journal of biomedical science · 2016Review
- Modeling the Progression of Epithelial Leak Caused by Overdistension.Cellular and molecular bioengineering · 2016Article
- Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.Frontiers in physiology · 2016Article
- Resistance to alveolar shape change limits range of force propagation in lung parenchyma.Respiratory physiology & neurobiology · 2015Article
- Spatial pattern formation in the lung.Journal of mathematical biology · 2015Article
- Airway and Extracellular Matrix Mechanics in COPD.Frontiers in physiology · 2015Review
- Mechanical interactions between adjacent airways in the lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Influence of parenchymal heterogeneity on airway-parenchymal interdependence.Respiratory physiology & neurobiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The explanted lung slice has become a popular in vitro system for studying how airways contract. Because the forces of airway-parenchymal interdependence are such important modulators of airway narrowing, it is of significant interest to understand how the parenchyma around a constricting airway in a lung slice behaves. We have previously shown that the predictions of the 2-dimensional distortion field around a constricting airway are substantially different depending on whether the parenchyma is modeled as an elastic continuum versus a network of hexagonally arranged springs, which raises the question as to which model best explains the lung slice. We treated lung slices with methacholine and then followed the movement of a set of parenchymal landmarks around the airway as it narrowed. The resulting parenchymal displacement field was compared to the displacement fields predicted by the continuum and hexagonal spring network models. The predictions of the continuum model were much closer to the measured data than were those of the hexagonal spring network model, suggesting that the parenchyma in the lung slice behaves like an elastic continuum rather than a network of discrete springs. This may be because the alveoli of the lung slice are filled with agarose in order to provide structural stability, causing the parenchyma in the slice to act like a true mechanical continuum. How the air-filled parenchyma in the intact lung behave in vivo remains an open question.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.