ArticleGynecologic oncology2013
Body mass index, physical activity, and survival after endometrial cancer diagnosis: results from the Women's Health Initiative.
Article in Gynecologic oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Technology-Supported Self-Guided Nutrition and Physical Activity Interventions for Adults With Cancer: Systematic Review.JMIR mHealth and uHealth · 2019Pooled it
- Weight Loss Randomized Intervention Trials in Female Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Pooled it
- Body mass index and mortality in endometrial cancer: A systematic review and meta-analysis.Gynecologic oncology · 2016Pooled it
- Global Patterns and Temporal Trends in Ovarian and Uterine Cancer Mortality Attributable to High Body-Mass Index, 1990-2023.Cancers · 2026Article
- Biobehavioral predictors of mood, pain, fatigue, and insomnia in endometrial cancer survivors.Gynecologic oncology · 2024Article
- Impact of weight loss after treatment on survival outcomes of overweight and obese patients with early‑stage endometrial cancer.Oncology letters · 2024Article
- Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Is Associated with Cervical Stromal Involvement in Endometrial Cancer Patients: A Cross-Sectional Study in South China.Current oncology (Toronto, Ont.) · 2023Article
- Prospective Cohort Study of Pre- and Postdiagnosis Obesity and Endometrial Cancer Survival.Journal of the National Cancer Institute · 2022Article
- Bariatric surgery in patients with breast and endometrial cancer in California: population-based prevalence and survival.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2022Article
- Prospective Cohort Study of Pre- and Postdiagnosis Physical Activity and Endometrial Cancer Survival.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Article
- Gynecologic cancer incidence and mortality among American Indian/Alaska Native women in the Pacific Northwest, 1996-2016.Gynecologic oncology · 2020Article
- Physical Activity and Mortality in Cancer Survivors: A Systematic Review and Meta-Analysis.JNCI cancer spectrum · 2020Article
- Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository.Cancer causes & control : CCC · 2019Article
- Sitting, physical activity, and serum oestrogen metabolism in postmenopausal women: the Women's Health Initiative Observational Study.British journal of cancer · 2017Observational
- Physical activity-related differences in body mass index and patient-reported quality of life in socioculturally diverse endometrial cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Health-related quality of life factors associated with completion of a study delivering lifestyle exercise intervention for endometrial cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative.PloS one · 2017Article
- Weight Change Pattern and Survival Outcome of Women with Endometrial Cancer.Annals of surgical oncology · 2016Article
- Obesity and colorectal cancer: molecular features of adipose tissue.Journal of translational medicine · 2016Review
- Associations between etiologic factors and mortality after endometrial cancer diagnosis: the NRG Oncology/Gynecologic Oncology Group 210 trial.Gynecologic oncology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveWhile low physical activity and high body mass index (BMI) have been associated with higher endometrial cancer incidence, no previous studies have evaluated the association between physical activity and survival after endometrial cancer diagnosis, and studies on BMI and survival have not been performed in a prospective cohort.
methodsWe examined pre-diagnosis BMI and moderate- to vigorous-intensity physical activity in relation to overall and disease-specific survival among 983 postmenopausal women who were diagnosed with endometrial cancer in the Women's Health Initiative Observational Study and Clinical Trials.
resultsOver a median 5.2 (max 14.1) years from diagnosis to death or end of follow-up, 163 total deaths were observed, 66 of which were due to endometrial cancer. We observed a higher all-cause mortality hazard ratio (HR) = 1.85 (95% CI 1.19-2.88) comparing women with a BMI ≥ 35 kg/m(2) to women with BMI< 25 kg/m(2). For endometrial cancer-specific mortality the HR = 2.23 (95% CI 1.09-4.54) comparing extreme BMI categories. To examine histologic subtypes we analyzed type I endometrial tumors separately and found an HR = 1.20 (95% CI 1.07-1.35) associated with all-cause mortality for each 5-unit change in BMI. Moderate- to vigorous-intensity physical activity was not associated with all-cause or endometrial cancer-specific mortality.
conclusionsPre-diagnosis BMI, but not physical activity, was associated with survival among women with endometrial cancer. Future studies should investigate mechanisms and timing of BMI onset to better understand the burden of disease attributable to BMI.
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