ReviewTrends in pharmacological sciences2013
Grand opening of structure-guided design for novel opioids.
Review in Trends in pharmacological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- The opioid receptor: emergence through millennia of pharmaceutical sciences.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Post-translational Modifications of Opioid Receptors.Trends in neurosciences · 2020Review
- Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands.ACS omega · 2019Article
- Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats.Psychopharmacology · 2019Article
- Article
- Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?Neuronal signaling · 2018Review
- Computational insights into the subtype selectivity and "message-address-efficacy" mechanisms of opioid receptors through JDTic binding and unbinding.Acta pharmacologica Sinica · 2018Article
- Pain States, the Opioid Epidemic, and the Role of Radiologists.Current pain and headache reports · 2018Review
- Computational insights into the G-protein-biased activation and inactivation mechanisms of the μ opioid receptor.Acta pharmacologica Sinica · 2018Article
- Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?Drug discovery today · 2017Review
- Synthesis and opioid receptor binding of indium (III) and [Tetrahedron · 2016Article
- Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.ACS chemical biology · 2016Article
- New Technologies for Elucidating Opioid Receptor Function.Trends in pharmacological sciences · 2016Review
- Molecular switches of the κ opioid receptor triggered by 6'-GNTI and 5'-GNTI.Scientific reports · 2016Article
- Opioid receptors: Structural and mechanistic insights into pharmacology and signaling.European journal of pharmacology · 2015Review
- Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms.ACS medicinal chemistry letters · 2015Article
- Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.Chemistry & biology · 2015Article
- Modulation of opioid-induced feeding behavior by endogenous nitric oxide in neonatal layer-type chicks.Veterinary research communications · 2015Article
- A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.Brain structure & function · 2015Article
- Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Twelve years after the publication of the first crystal structure of a G-protein-coupled receptor (GPCR), experimental crystal structures of the four opioid receptor subtypes have made their entrance into the literature in the most extraordinary way, that is, all at once. Not only do these crystal structures contribute unprecedented molecular details of opioid ligand binding and specificity, but they also represent important tools for structure-based approaches to guide the discovery of safer and more efficient opioid therapeutics. We provide here an overview of these latest breakthroughs in the structural biology of GPCRs with a focus on differences and similarities between the four opioid receptor structures, as well as their limitations, in the context of challenges for translation of this new knowledge from bench to bedside.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.