ReviewMolecular immunology2013
Diverse antigen presentation by the Group 1 CD1 molecule, CD1c.
Review in Molecular immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Unveiling Immune Response Mechanisms in Mpox Infection Through Machine Learning Analysis of Time Series Gene Expression Data.Life (Basel, Switzerland) · 2025Article
- Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses.Biomolecules · 2025Review
- Identification of immune-related hub genes and potential molecular mechanisms involved in COVID-19 via integrated bioinformatics analysis.Scientific reports · 2024Article
- Article
- Genomic landscape and expression profile of consensus molecular subtype four of colorectal cancer.Frontiers in immunology · 2023Article
- Presence of Dendritic Cell Subsets in Sentinel Nodes of Breast Cancer Patients Is Related to Nodal Burden.International journal of molecular sciences · 2022Article
- Review
- CD1: A Singed Cat of the Three Antigen Presentation Systems.Archivum immunologiae et therapiae experimentalis · 2017Review
- Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1cInfection and immunity · 2017Article
- Natural killer T cells in atherosclerosis.Nature reviews. Cardiology · 2017Review
- Plasmodium falciparum Infection of Human Volunteers Activates Monocytes and CD16+ Dendritic Cells and Induces Upregulation of CD16 and CD1c Expression.Infection and immunity · 2015Article
- Increased CD1c+ mDC1 with mature phenotype regulated by TNFα-p38 MAPK in autoimmune ocular inflammatory disease.Clinical immunology (Orlando, Fla.) · 2015Article
- The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity.Frontiers in immunology · 2015Review
- Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The CD1 size problem: lipid antigens, ligands, and scaffolds.Cellular and molecular life sciences : CMLS · 2014Review
- Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody.Immunological investigations · 2014Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
CD1 molecules are Major Histocompatibility Complex (MHC) class I-like proteins that present diverse lipid antigens to T cells. Most of our understanding of CD1 lipid presentation and T cell recognition has come from study of the invariant Natural Killer T cell recognition of CD1d. However, in addition to CD1d, humans possess three additional CD1 molecules: CD1a, CD1b and CD1c, referred to as the Group 1 CD1s. The lack of an appropriate murine molecule to probe the function and disease relevance of these molecules has hindered understanding their precise immunological role, despite their pivotal role in human immunity. In this perspective, we discuss the progress of functional and molecular studies of CD1c. CD1c has been shown to specifically present lipids from Mycobacterium tuberculosis and other related pathogenic mycobacteria. αβ T cells reactive to these lipids presented in the context of CD1c have been characterized and upon stimulation secrete IFN-γ, an important cytokine in tuberculosis disease clearance. Other ligands characterized for CD1c include PI and PC, a lipopeptide with a dodecameric peptide moiety and sulfatides. These structurally and chemically diverse ligands suggest that CD1c has the capacity to present a wide repertoire of antigens to reactive T cells. Indeed, a substantial percentage (∼2%) of the circulating αβ T cell population is reactive to CD1c presenting endogenous antigens, suggesting that this particular Group 1 molecule may play an important role in the human immune response.
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Registered trials
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