ReviewNeuroscience and biobehavioral reviews2013
Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging.
Review in Neuroscience and biobehavioral reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03162692 (Preoperative Anxiety's Incidence and Related Factors in Surgical Patients), which is not on this map. Cited by 82 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preoperative Anxiety's Incidence and Related Factors in Surgical Patients
Who cites it
82 citing papers in PubMed.
- Depression and Anxiety Screens as Simultaneous Predictors of 10-Year Incidence of Diabetes Mellitus in Older Adults in Primary Care.Journal of the American Geriatrics Society · 2017Trial
- Using the stress and adversity inventory as a teaching tool leads to significant learning gains in two courses on stress and health.Stress and health : journal of the International Society for the Investigation of Stress · 2014Trial
- Family background and peer victimization are associated with generalized trust from adolescence to adulthood.Communications psychology · 2026Article
- Stimulated cytokine production, attachment, and emotional well-being in dementia spousal caregivers.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Associations between symptoms of depression and anxiety with left ventricular hypertrophy among Hispanic/Latino participants of the Hispanic Community Health Study/Study of Latinos.medRxiv : the preprint server for health sciences · 2026Article
- Mediating effect of fear of happiness between intolerance of uncertainty and anxiety among Lebanese adults.Global mental health (Cambridge, England) · 2026Article
- Resilience as a Mediator Between Childhood Trauma and Adult Psychopathology: The Moderating Role of Harm Avoidance in Korean Adults.Brain sciences · 2025Article
- Low mood, not anxiety, connected with micro facial expression recognition.Scientific reports · 2025Article
- Psychological symptoms, comorbidities and symptom items associated with self-reported mental health needs in college students.BMC psychiatry · 2025Article
- Associations of lifetime stressors and health behaviors with inflammation in young adults previously placed in youth residential care.Brain, behavior, & immunity - health · 2025Article
- Threat-related attentional bias in subjects with different looming cognitive styles: Evidence based on eye-tracking study.World journal of psychiatry · 2025Article
- Adverse childhood experiences, inflammation, and depression: evidence of sex- and stressor specific effects in a nationally representative longitudinal sample of U.S. adolescents.Psychological medicine · 2025Article
- Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study.Translational psychiatry · 2025Article
- Cyclic patterns of high-risk behaviours within ballet culture.BMC psychology · 2025Article
- Trajectory of peripheral inflammation during index ECT in association with clinical outcomes in treatment-resistant depression.Brain, behavior, & immunity - health · 2025Article
- A preliminary investigation of worry, cortical amyloid burden, and stressor-evoked brain and cardiovascular reactivity in older adults.Journal of affective disorders · 2024Article
- Addressing Mental Health in Rural Settings: A Narrative Review of Blueberry Supplementation as a Natural Intervention.Nutrients · 2024Review
- Inflammatory markers changes following acceptance-based behavioral psychotherapy in generalized anxiety disorder patients: Evidence from a randomized controlled trial.Brain, behavior, & immunity - health · 2024Article
- Associations of Anxiety Symptoms With 6-Year Blood Pressure Changes and Incident Hypertension: Results From the Hispanic Community Health Study/Study of Latinos.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024Article
- Association of mental health-related patient reported outcomes with blood pressure in adults and children with primary proteinuric glomerulopathies.Journal of nephrology · 2024Observational
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Anxiety disorders increase risk for the early development of several diseases of aging. Elevated inflammation, a common risk factor across diseases of aging, may play a key role in the relationship between anxiety and physical disease. However, the neurobiological mechanisms linking anxiety with elevated inflammation remain unclear. In this review, we present a neurobiological model of the mechanisms by which anxiety promotes inflammation. Specifically we propose that exaggerated neurobiological sensitivity to threat in anxious individuals may lead to sustained threat perception, which is accompanied by prolonged activation of threat-related neural circuitry and threat-responsive biological systems including the hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), and inflammatory response. Over time, this pattern of responding can promote chronic inflammation through structural and functional brain changes, altered sensitivity of immune cell receptors, dysregulation of the HPA axis and ANS, and accelerated cellular aging. Chronic inflammation, in turn, increases risk for diseases of aging. Exaggerated neurobiological sensitivity to threat may thus be a treatment target for reducing disease risk in anxious individuals.
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